摘要
目的:观察自拟益气养阴消癥通络方对糖尿病肾病(DN)的影响。方法:选择潜江市中心医院2018年7月-2020年12月收治的90例DN患者,按照数字表法随机分为对照组和观察组,各45例。对照组患者入院后均予以综合措施治疗,观察组在对照组基础上加用自拟益气养阴消癥通络方治疗,两组疗程均为3个月。比较两组患者治疗前后中医症状积分、肾功能指标、微炎症状态及氧化应激指标。结果:两组患者治疗后中医症状积分、肾功能指标[24 h尿蛋白定量(24 h UAE)、尿白蛋白排泄率(UAER)、血尿素氮(BUN)、血肌酐(Scr)]、微炎症状态指标[白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]均降低,差异有统计学意义(P<0.05),且观察组患者治疗后中医症状积分、肾功能指标、微炎症状态指标降低较对照组更明显,差异有统计学意义(P<0.05);两组患者治疗后超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平较治疗前升高,而丙二醛(MDA)水平较治疗前降低,差异有统计学意义(P<0.05),且观察组患者治疗后SOD、GSH-Px水平升高和MDA水平降低较对照组治疗后更明显,差异有统计学意义(P<0.05)。结论:自拟益气养阴消癥通络方不但可改善DN患者临床症状和肾功能,而且还可明显减轻微炎症状态和氧化应激反应,且具有较高的安全性。
Objective:To observe the effect of self-made Yiqi Yangyin Xiaozheng Tongluo Recipe on diabetic nephropathy(DN).Method:A total of 90 patients with DN admitted to Qianjiang Central Hospital from July 2018 to December 2020 were randomly divided into control group and observation group according to the number table method,with 45 cases in each group.The patients in the control group were treated with comprehensive measures after admission,and the observation group was treated with self-made Yiqi Yangyin Xiaozheng Tongluo Recipe on the basis of the control group.The treatment course of the two groups was 3 months.The scores of TCM symptoms,renal function indexes,micro-inflammatory status and oxidative stress indexes were compared between the two groups of patients before and after treatment.Result:After treatment,the TCM symptom scores renal function indexes[24 h urinary albumin excretion(24 h UAE),urinary albumin excretion rate(UAER),blood urea nitrogen(BUN),serum creatinine(Scr)],and micro-inflammatory status indexes[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]of the two groups were reduced,and the differences were statistically significant(P<0.05).After treatment,the TCM symptom scores,renal function indexes and micro inflammation indexes in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the two groups were higher than those before treatment,and the levels of malonic dialdehyde(MDA)were lower than those before treatment,the difference were statistically significant(P<0.05),and the levels of SOD and GSH-Px increased and MDA decreased in observation group were more obvious than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:The self-made Yiqi Yangyin Xiaozheng Tongluo Recipe can not only improve the clinical symptoms and renal function
作者
文静
刘妍
WEN Jing;LIU Yan(Qianjiang Central Hospital,Qianjiang 433199,China;不详)
出处
《中外医学研究》
2022年第20期38-42,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
自拟益气养阴消癥通络方
糖尿病肾病
微炎症状态
氧化应激
Self-made Yiqi Yangyin Xiaozheng Tongluo Recipe
Diabetic nephropathy
Micro-inflammatory state
Oxidative stress
