摘要
目的 研究与糖尿病肾病(DiabeticNephropathy ,DN)相关的危险因素;评价β2 微球蛋白与微量白蛋白尿诊断糖尿病肾病的相关性。方法 根据2 4h尿白蛋白排泄率(UAER)及尿蛋白定量将88例2型糖尿病患者分为单纯糖尿病组(A组)、早期糖尿病肾病组(B组)和临床糖尿病肾病组(C组) ,对其临床及生化指标进行多元逐步回归分析。结果 ①C组或B组与A组间空腹胰岛素(FINS)、空腹C肽(FC- P)、收缩压(SBP)、舒张压(DBP)、年龄、病程、并发症及肾功能差异均有显著性意义;②与DN相关的危险因素依次为收缩压、空腹C肽、糖化血红蛋白、病程;③β2 微球蛋白(β2 MG)与UAER及肾功能指标相关性良好。结论 高血压、高C肽水平、血糖控制不良及病程是DN发病的危险因素;β2 微球蛋白可作为DN早期的辅助诊断指标。
Objective To investigate the correlated risk factors about diabetic nephropathy(DN) of type 2 diabetes(T_2DM); To evaluate the correlation of β_2-microglobulin and urinary albumin excretion rate(UAER) in diagnosing DN. Methods Eighty-eight patients of T_2DM were divided into three groups: T_2DM without DN(groupA),T_2DM with DN in initial stage(groupB) and T_2DM with DN in clinical stage(groupC) according to UAER and urinary protein in 24-hour measurement. The clinical and biochemical indexes were analyzed with multivariable stepwise regression method. Results The fasting insulin (F-INS), the fasting C peptide (FC-P), SBP, DBP, age, the diabetic course, number of complication and renal function indexes was significantly higher in groupC or groupB than in groupA;the stepwise regression analysis showed that SBP, FC-P, glucosylated hemoglobin (HbA1c) and diabetic course were significantly positively correlated with DN; β_2-microglobulin were significantly positively correlated with UAER and renal function index. Conclusion hypertension, the increase levels of FC-P, blood sugar and diabetic duration was risk factors of DN; β_2-microglobulin can be a sensitive index in diagnosing initial stages of DN.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第2期272-274,283,共4页
Suzhou University Journal of Medical Science
关键词
糖尿病肾病
白蛋白尿
危险因素
Β2微球蛋白
diabetic nephropathy
urinary albumin excretion rate(UAER)
risk factors
β_2-microglobulin
