摘要
目的探讨结直肠腺癌不同浸润模式与临床病理特征之间的相关性。方法收集2007-01—2020-02珠海市中西医结合医院收治的结直肠腺癌标本152例,患者年龄29~93岁,依据肿瘤浸润模式,分为破坏性浸润和膨胀性浸润,分析不同浸润模式与患者性别、年龄、肿瘤最大径、临床分期、淋巴结转移、神经脉管侵犯、肿瘤分化及浸润深度之间的关系。结果①不同浸润模式的肿瘤最大径(χ^(2)=9.45,P=0.01)、临床分期(χ^(2)=41.25,P=0.00)、淋巴结转移(χ^(2)=36.83,P=0.00)、神经侵犯(χ^(2)=26.14,P=0.00)、脉管癌栓(χ^(2)=35.72,P=0.00)、肿瘤分化(χ^(2)=8.11,P=0.02)之间均有统计学差异(P<0.05),而与患者性别、年龄、肿瘤浸润深度在不同浸润模式中均无统计学差异(P>0.05)。②中分化结直肠腺癌不同浸润模式的淋巴结转移率有统计学差异(χ^(2)=30.51,P=0.00)。结论破坏性浸润的结直肠腺癌往往具有更高的临床分期、淋巴结转移率及神经脉管侵犯,即使肿瘤很小,病理医师也需关注肿瘤的生长方式,尤其对于中分化腺癌,建议在病理报告中描述结直肠腺癌的浸润模式,以提示其预后。
Objective To investigate the correlation of different infiltration patterns of colorectal adenocarcinoma and clinicopathological features.Methods Data obtained from Zhuhai Hospital of Traditional Chinese and Western Medicine were analyzed,including 152 colorectal adenocarcinoma cases collected from January 2007 to Feburary 2020.The age of patients ranged 29-93 years.According to infiltration patterns,the tumor was divided into two groups:destructive invasion and expansive invasion.The relationship between different infiltration patterns and gender,age,maximum tumor diameter,clinical stage,lymph node metastasis,nerve/vascular invasion,tumor differentiation and depth of tumor invasion was analyzed.Results There were statistically significant differences(P<0.05)in maximum tumor diameter(χ^(2)=9.45,P=0.01),clinical stage(χ^(2)=41.25,P=0.00),lymph node metastasis(χ^(2)=36.83,P=0.00),nerve invasion(χ^(2)=26.14,P=0.00),vascular tumor emboli(χ^(2)=35.72,P=0.00)and tumor differentiation(χ^(2)=8.11,P=0.02)of different infiltration patterns.But there were no statistically significant differences(P>0.05)in gender or age of patients or depth of tumor invasion.There were statistically significant differences in lymph node metastasis rates among different infiltration patterns of moderately differentiated colorectal adenocarcinoma(χ^(2)=30.51,P=0.00).Conclusion Colorectal adenocarcinoma with destructive invasion tends to have a higher clinical stage,lymph node metastasis rate and nerve/vascular invasion.Even if the tumor is small,the pathologists should pay attention to the growth pattern of tumor,and it is recommended to describe the infiltration pattern of the colorectal adenocarcinoma in the pathological reports to indicate its prognosis,especially for moderately differentiated adenocarcinoma.
作者
吕威
秦玉晶
杜瑞
范思格
李玉梅
LV Wei;QIN Yu-jing;DU Rui;FAN Si-ge;LI Yu-mei(Department of Pathology,Guangdong Women and Children Hospital,Guangzhou 511400,China;Dapartment of Gastroenterology,Heilongjiang Provincial Hospital,Harbin 150036,China;Department of Pathology,Zhuhai Hospital of Traditional Chinese and Western Medicine/Second People’s Hospital of Zhuhai,Zhuhai 519000,China)
出处
《诊断病理学杂志》
2022年第7期593-597,共5页
Chinese Journal of Diagnostic Pathology
关键词
结直肠腺癌
浸润模式
临床分期
分化
预后
Colorectal adenocarcinoma
Infiltration pattern
Clinical stage
Differentiation
Prognosis
