摘要
骨细胞外基质是一种细胞黏附、增殖和分化的场所。利用无机非金属材料和可降解聚合物模仿其生理特性和组织结构,改善机械、生物性能,已成为设计和研发支架的一种较为实用的方法。选择性能合适的支架材料相当重要。珍珠粉组成、结构类似天然骨。自Lopez发现以来,学者通过体内与体外研究,证明了珍珠粉具有优于羟基磷灰石的成骨性能和生物相容性,是一种较为理想的无机非金属骨支架材料。它能均匀分散于支架,提供了成骨的主要原料和骨引导的多孔环境,使表面粗糙,从而提高了力学性能和亲水性,也能促进细胞的增殖分化,调节支架的理化和生理学性能。目前研究较多的为珍珠粉/聚乳酸复合支架以及珍珠粉/壳聚糖-透明质酸复合支架。同时,不少支架已开始载入生长因子提高成骨效果,载入缓释药物探寻抗感染、抗肿瘤的方法,以及使用三维打印令孔隙形状更适合细胞长入和力学性能改善。但种子细胞的研究,元素掺杂的研究,力、电、磁等物理刺激作为组织工程第四元素的研究等,尚少见于珍珠粉复合支架。本文通过对国内外文献的回顾,对珍珠粉复合支架在骨组织修复的研究进展进行了系统综述。
Bone extracellular matrix is a place for cell adhesion,proliferation and differentiation.Using Inorganic nonmetallic materials and degradable polymer to imitate its physiological characteristics and tissue structure,improve mechanical properties and biocompatibility has become a more practical method to design and develop scaffolds.It is very important to choose the scaffold material with appropriate performance.Pearl powder is similar to natural bone in composition and structure.Since Lopez’s discovery,scholars have proved that pearl powder has better osteogenic properties and biocompatibility than hydroxyapatite through in vivo and in vitro studies,and it is an ideal inorganic non-metallic bone scaffold material.It can be evenly dispersed in the scaffold,provide the main raw material for osteogenesis and the porous environment for bone guidance,make the surface rough,improve the mechanical properties and hydrophilicity,and promote the value-added differentiation of cells,so as to adjust the physical,chemical and physiological properties of the scaffold.It can be evenly dispersed in the scaffold,providing the main raw materials for osteogenesis and the porous environment for bone guidance,making the surface rough,so as to improve the mechanical properties and hydrophilicity,promote the proliferation and differentiation of cells,and toregulate the physical,chemical and physiological properties of the scaffold.At present,pearl powder/polylactic acid composite scaffolds and pearl powder/chitosan-hyaluronic acid composite scaffolds are more studied.At the same time,many scaffolds have begun to load growth factors to improve the osteogenic effect,load sustained-release drugs to explore anti-infection andanti-tumor methods,and use threedimensional printing to make the pore shape more suitable for the growth of cells and the improvement of mechanical properties.However,the research on seed cells,element doping and physical stimulation such as force,electricity and magnetism as the fourth element of tissue engineering
作者
张楷
徐普
ZHANG Kai;XU Pu(Dental Implant Department,Hainan Dental Medical Center,Dental Center,Affiliated Haikou Hospital,Xiangya Medical College,Central South University,Haikou 570208,China)
出处
《口腔颌面修复学杂志》
2022年第4期297-302,315,共7页
Chinese Journal of Prosthodontics
基金
国家自然科学基金(项目编号:82060194)。
关键词
珍珠粉
植骨材料
组织工程
pearl powder
bone substitute
tissue engineering
