摘要
目的了解北京市海淀区2012-2019年肠道门诊腹泻患者病毒感染情况和流行趋势。方法采集北京市海淀区某哨点医院2012-2019年肠道门诊腹泻患者的粪便样本,使用实时荧光定量PCR检测A组轮状病毒、诺如病毒、札如病毒、星状病毒和肠道腺病毒,并对结果进行统计学分析。结果982例腹泻患者的粪便样本中检出阳性样本314例,病毒总检出率为31.98%。五种病毒检出率依次为诺如病毒(19.76%)、A组轮状病毒(9.78%)、札如病毒(0.92%)、星状病毒(0.31%)和肠道腺病毒(0.10%)。不同性别及各年龄组的检出率差异无统计学意义(P>0.05)。诺如病毒和轮状病毒在冬季和春季高发,札如病毒、星状病毒和肠道腺病毒检出率较低。结论病毒性腹泻全年都可能发生,不同性别及各年龄组均可感染。海淀区肠道门诊腹泻患者中感染诺如病毒和轮状病毒的病例较多。今后应进一步加强病毒性腹泻的监测工作。
Objective To understand the viral infection and epidemiological trends of diarrhea patients in intestinal disease outpatient clinic in Haidian district of Beijing from 2012 to 2019.Methods Stool specimens from patients with intestinal diarrhea were collected from one sentinel hospital in Haidian district of Beijing from 2012 to 2019.Quantitative realtime PCR was used to detect rotavirus,norovirus,sapovirus,astrovirus and adenovirus,and the data were analyzed statistically.Results A total of 314 positive samples were detected from 982 stool specimens,with a total positive detection rate of 31.98%.The positive detection rates of novoviurs,rotavirus,sapovirus,astrovirus and adenovirus were 19.76%,9.78%,0.92%,0.31%and 0.10%respectively.There was no significant difference in positive detection rate among different genders and age groups(P>0.05).Rotavirus and norovirus mostly occurred in winter and spring.The positive detection rate for sapovirus,astrovirus and adenovirus was extremely low.Conclusions Viral diarrhea can occur throughout the year and in all genders and age groups.There are more people infected with norovirus and rotavirus than those infected with other three kinds of virus among diarrhea patients in intestinal disease outpatient clinics in Haidian district.In the future,it is necessary to further strength the surveillance of viral diarrhea.
作者
韩思媛
钟磊
杜申君
何梓瑶
HAN Si-yuan;ZHONG Lei;DU Shen-jun;HE Zi-yao(Haidian District Center for Disease Prevention and Control,Beijing 100094,China)
出处
《首都公共卫生》
2022年第3期169-172,共4页
Capital Journal of Public Health
