摘要
目的:观察理肺通络方联合阿奇霉素治疗儿童风热肺闭型肺炎支原体肺炎的临床疗效及对细胞因子IL-4、IL-8、IL-10的影响,探讨其作用机制。方法:选取符合风热闭肺型肺炎支原体肺炎中西医纳入标准的住院患儿80例,随机分为治疗组(40例)和对照组(40例),各组均予阿奇霉素治疗,治疗组予理肺通络方口服,对照组予小儿肺热咳喘颗粒口服,治疗12d后,对比两组临床疗效、症状及体征总积分变化、主症及肺部体征消失时间、住院天数、血清中IL-4、IL-8及IL-10水平及不良反应发生率。结果:治疗组40例,痊愈28例,显效7例,有效2例,无效3例,总有效率92.50%;对照组40例,痊愈21例,显效5例,有效5例,无效9例,总有效率77.50%,两组疗效比较,治疗组优于对照组(P<0.05);治疗后,两组患儿症状总积分均较治疗前降低(P<0.05),且治疗组低于对照组(P<0.05);患儿在发热、咳嗽、肺部体征消失时间及住院天数上,治疗组均低于对照组(P<0.05),两组患儿IL-4、IL-8、IL-10水平均较治疗前下降,且治疗组低于对照组(P<0.05);治疗组的不良反应发生率低于对照组(P<0.05)。结论:理肺通络方可以明显改善风热闭肺型肺炎支原体肺炎患儿的临床症状,减轻炎症反应,缩短住院时间,可有效治疗风热闭肺型肺炎支原体肺炎,且不良反应发生率低。
Objective:To observe the clinical efficacy of Lifei Tongluo decoction combined with azithromycin in the treatment of syndrome of wind-heat invading the lung mycoplasma pneumoniae pneumonia in children,and its effect on cytokines IL-4,IL-8,IL-10.then to explore its mechanism.Methods:Choosing 80hospitalized children with syndrome of wind-heat invading the lung mycoplasma pneumoniae pneumonia who met the inclusion criteria of traditional Chinese and western medicine were randomly divided into treatment group(n=40)and control group(n=40).Both groups were treated with azithromycin,the treatment group was treated with Lifei Tongluo Decoction,and the control group was treated with Xiao,er Feire Kechuan granule.After 12days of treatment,compared the clinical efficacy,the changes of total score of symptoms and signs,the disappearance time of main symptoms and pulmonary signs,the days of hospitalization,the level of IL-4,IL-8and IL-10in serum before and after treatment and the incidence of adverse reactions between the two groups.Results:In the treatment group,28cases were cured,7cases were markedly effective,2cases were effective,3cases were ineffective,the total effective rate was 92.50%,while in the control group,21cases were cured,5cases were markedly effective,5cases were effective,9cases were ineffective,and the total effective rate was77.50%(P<0.05).After the treatment,the total symptom scores of the two groups were lower than before treatment(P<0.05),and the total symptom score in the treatment group was lower than the control group(P<0.05).The fever,cough,disappearance time of pulmonary signs and hospitalization days in the treatment group were less than those in the control group(P<0.05).The levels of serum inflammatory indexes IL-4,IL-8and IL-10in the two groups were lower than before treatment,and those in the treatment group were lower than the control group(P<0.05).The incidence of adverse reactions in the treatment group was lower than the control group(P<0.05).Conclusion:Lifei Tongluo decoction can signific
作者
田新磊
朱珊
赵文锦
祝志朋
Tian Xinlei;Zhu Shan;Zhao Wenjin;Zhu Zhipeng(Department of Pediatrics,Henan Province Hospital of TCM,Zhengzhou 450000,China;Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《亚太传统医药》
2022年第7期95-99,共5页
Asia-Pacific Traditional Medicine
基金
河南省高等学校重点科研项目(19A360005)。
关键词
理肺通络方
风热闭肺型
肺炎支原体肺炎
Lifei Tongluo Decoction
Syndrome of Wind-Heat Invading the Lung
Mycoplasma Pneumoniae Pneumonia
