摘要
目的 分析氯吡格雷对急性心肌梗死患者血清炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及血管细胞粘附分子-1(sVCAM-1)水平的影响。方法 80例急性心肌梗死患者,随机分为对照组和观察组,各40例。对照组给予常规治疗,观察组在对照组基础上增加氯吡格雷治疗。比较两组患者临床疗效及治疗前后炎性因子、sVCAM-1水平。结果 治疗前,两组hs-CRP、IL-6、TNF-α、sVCAM-1水平比较差异无统计学意义(P>0.05);治疗后,两组hs-CRP、IL-6、TNF-α、sVCAM-1水平均明显低于治疗前,且观察组hs-CRP(5.16±1.08)mg/L、IL-6(7.24±5.76)μg/L、TNF-α(173.02±74.52)pg/ml、sVCAM-1(436.52±83.71)μg/ml均明显低于对照组的(6.98±1.89)mg/L、(9.86±6.98)μg/L、(249.63±81.32)pg/ml、(486.04±83.25)μg/ml,差异具有统计学意义(P<0.05)。观察组总有效率95.0%明显高于对照组的75.0%,差异有统计学意义(P<0.05)。结论 氯吡格雷治疗急性心肌梗死的疗效显著,可有效改善患者的心肌炎性反应,值得在临床上推广应用。
Objective To analyze the effect of clopidogrel on inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and soluble vascular cell adhesion molecule-1(VCAM-1)levels in patients with acute myocardial infarction.Methods A total of 80 patients with acute myocardial infarction were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with clopidogrel on the basis of the control group.The clinical efficacy and the levels of inflammatory factors and sVCAM-1 before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of hs-CRP,IL-6,TNF-αand sVCAM-1 between the two groups(P>0.05).After treatment,the levels of hs-CRP,IL-6,TNF-αand sVCAM-1 in the two groups were significantly lower than those before treatment in this group;the hs-CRP(5.16±1.08)mg/L,IL-6(7.24±5.76)μg/L,TNF-α(173.02±74.52)pg/ml,and sVCAM-1(436.52±83.71)μg/ml in the observation group were significantly lower than(6.98±1.89)mg/L,(9.86±6.98)μg/L,(249.63±81.32)pg/ml,and(486.04±83.25)μg/ml in the control group;all the differences were statistically significant(P<0.05).The total effective rate of the observation group was 95.0%,which was significantly higher than 75.0%of the control group,and the difference was statistically significant(P<0.05).Conclusion Clopidogrel has significant efficacy in the treatment of acute myocardial infarction,and can effectively improve the myocardial inflammatory response,which is worthy of clinical promotion and application.
作者
张蕊
ZHANG Rui(Department of Internal Medicine,The First Hospital of Xifeng County,Tieling 112499,China)
出处
《中国实用医药》
2022年第15期103-105,共3页
China Practical Medicine
关键词
氯吡格雷
急性心肌梗死
炎性因子
血管细胞粘附分子-1
Clopidogrel
Acute myocardial infarction
Inflammatory factors
Soluble vascular cell adhesion molecule-1
