摘要
目的观察硫酸氢氯吡格雷片联合阿司匹林治疗急性心肌梗死的疗效,并探讨其对患者心肌功能和血清炎性因子的影响。方法将我院收治的50例急性心肌梗死患者随机分为试验组和对照组,各25例。对照组给予阿司匹林,每次300 mg,每天1次,口服;试验组在对照组的基础上给予硫酸氢氯吡格雷,每次300 mg,每天1次,口服。治疗3 d后调整剂量,2组均治疗1个月。观察2组患者治疗前后C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子α(TNF-α)水平,用多普勒超声测量患者的左心室射血分数(LVEF)、心输出量(CO)、左心室收缩末期内径(LVESD)和左心室舒张末期内径(LVEDD);同时检测患者治疗前后凝血指标,包括血浆P-选择素(P-selectin),D-二聚体(D-D)和血浆假性血友病因子(vWF)。结果治疗后,对照组和试验组LVEF分别为(42.15±7.62)%和(49.25±6.50)%,CO分别为(4.76±0.57)和(5.23±0.45)L·min^-1,LVESD分别为(45.37±4.23)和(40.85±4.98)mm,LVEDD分别为(48.74±4.53)和(45.64±5.12)mm,差异均有统计学意义(均P<0.05)。治疗后,2组患者的血清炎性因子和凝血功能恢复情况差异均有统计学意义(均P<0.05)。试验组出现恶心1例,低血压1例,药物不良反应发生率为8.00%;对照组出现恶心1例,头痛1例,低血压1例,药物不良反应发生率为12.00%。2组药物不良反应发生率差异无统计学意义(P>0.05)。结论硫酸氢氯吡格雷片联合阿司匹林治疗急性心肌梗死能有效改善患者心肌功能和凝血功能,同时能有效抑制血清炎性因子的表达。
Objective To observe the clinical efficacy of clopidogrel hydrogen sulfate and aspirin in the treatment of patients with acute myocardial infarction,and explore its effect on myocardial function and serum inflammatory factors.Methods Fifty patients with acute myocardial infarction admitted to our hospital were randomly divided into treatment group and control group,with 25 patients in each group.Control group was treated with aspirin 300 mg,once a day,orally.Treatment group was treated with hydroclopidogrel sulfate 300 mg,once a day,orally,on the basis of control group.Adjust the dose after 3 d of treatment,two groups were all treated for 1 month.The changes of C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)were observed before and after treatment,the left ventricular function(LVEF),cardiac output(CO),left ventricular end-systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)were measured by doppler ultrasound,the plasma P-selectin,D-dimmer(D-D)levels and von willebrand factor(vWF)were measured before and after treatment.Results After treatment,the LVEF in control group and treatment group were(42.15±7.62)% and(49.25±6.50)%,CO were(4.76±0.57)and(5.23±0.45)L·min^-1,LVESD were(45.37±4.23)and(40.85±4.98)mm,LVEDD were(48.74±4.53)and(45.64±5.12)mm,all with significant difference(all P<0.05).After treatment,the inflammatory mediators and coagulation parameters of patients in two group were all with significant difference(all P<0.05).There were 1 case of nausea,1 case of hypotension in treatment group,with the incidence of 8.00%;there were 1 case of nausea,1 case of headache and 1 case of hypotension in control group,with the incidence of 12.00%.There was no significant difference in the incidence of adverse drug reactions in two groups(P>0.05).Conclusion Clopidogrel hydrogen sulfate combined with aspirin in the treatment of acute myocardial infarction can effectively improve myocardial function and coagulation functions of patients,and can effectively inhibit the e
作者
李晓渝
储岳峰
胡文杰
LI Xiao-yu;CHU Yue-feng;HU Wen-jie(Department of Cardiovascular Medicine,Lu’an People’s Hospital,Lu’an 237000,Anhui Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第15期2182-2185,共4页
The Chinese Journal of Clinical Pharmacology
关键词
硫酸氢氯吡格雷片
急性心肌梗死
炎性因子
阿司匹林
clopidogrel hydrogen sulfate tablet
acute myocardial infarction
inflammatory factor
aspirin
