摘要
骨骼肌卫星细胞(muscle satellite/stem cells,MuSCs)介导的再生和修复对骨骼肌损伤后完整肌肉功能的恢复至关重要。在多种病理生理过程中,内质网应激(endoplasmic reticulum stress,ERS)诱导的未折叠蛋白质反应(unfolded protein response,UPR)和自噬能够清除积累的错误折叠的蛋白质,是细胞维持稳态的重要机制。近年来,越来越多的研究发现在骨骼肌再生过程中内质网应激和自噬被激活,且在肌再生过程中发挥重要的调控作用,对损伤后肌肉的修复至关重要。本文主要针对近年来内质网应激和自噬在肌再生过程中的作用的研究进展做一综述,旨在为研发以内质网应激和自噬为靶点改善骨骼肌再生的药物提供理论依据。
Satellite cell-mediated regeneration and repair is essential for the restoration of intact muscle function after injury.In a variety of pathophysiological processes,the unfolded protein response(UPR)and autophagy induced by endoplasmic reticulum stress(ERS)can remove accumulated dysfunctional proteins,both of which are important mechanisms for maintaining cell homeostasis.In recent years,more and more studies have found that ERS and autophagy are activated during skeletal muscle regeneration,and play an important regulatory role in the process of muscle regeneration,which is essential for the repair of injured muscles.This paper mainly reviewed the research progress of the role of ERS and autophagy in muscle regeneration in recent years,and aimed to provide a theoretical basis for therapeutic strategies to improve skeletal muscle regeneration by regulating endoplasmic reticulum stress and autophagy.
作者
李春杰
江振洲
LI Chunjie;JIANG Zhenzhou(Institute of Pharmaceutical Sciences,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学研究》
CAS
2022年第7期472-476,共5页
Journal of Pharmaceutical Research
基金
江苏省“六大人才高峰”高层次人才选拔培养(No.SWYY-094)。
关键词
卫星细胞
骨骼肌损伤
骨骼肌再生
内质网应激
未折叠蛋白质反应
自噬
Satellite cell
Skeletal muscle injury
Skeletal muscle regeneration
Endoplasmic reticulum stress
Unfolded protein response
Autophagy
