摘要
内质网(ER)是细胞中的细膜系统,它功能强大,在蛋白质合成和折叠、新生肽链的组装和运输、钙离子浓度的存储和调节中起重要作用。近年来越来越多的研究发现内质网应激(ERS)和未折叠蛋白反应(UPR)在肠内稳态中的表达及其对炎症性肠病(IBD)的发病机理起重要作用。本文就内质网应激相关机制及其在IBD发生中的作用作一综述。
Endoplasmic reticulum(ER) is a thin membrane system in cells. It is powerful and plays an important role in protein synthesis and folding, assembly and transportation of nascent peptide chains,and storage and regulation of calcium ion concentration. In recent years, more and more studies have found that endoplasmic reticulum stress(ERS) and unfolded protein response(UPR) expression in intestinal homeostasis and it’s importance to the pathogenesis of inflammatory bowel disease(IBD).This article reviews the mechanisms of ERS and its role in the development of IBD.
作者
曹攀
龚作炯
CAO Pan;GONG Zuojiong(Dept.of Infectious Disease,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2021年第5期851-856,共6页
Medical Journal of Wuhan University
基金
国家自然科学基金资助项目(编号:8187032070)。
关键词
炎症性肠病
内质网应激
未折叠蛋白质反应
细胞凋亡
Inflammatory Bowel Disease
Endoplasmic Reticulum Stress
Unfolded Protein Reaction
Apoptosis
