摘要
目的 2020年在宁夏流行性出血热自然疫源地县区开展一般人群流行性出血热抗体水平调查,了解辖区居住一般人群免疫水平。方法 采用分层整群随机抽样方法,抽取宁夏近年来流行性出血热自然疫源地和近年来有病例报告的6个县(区)18个乡镇36个村,每个村随机抽取25人,每人采集静脉血4 mL,采用酶联免疫吸附试验(ELISA)检测血清流行性出血热IgG抗体。结果 本次调查共采集962份一般人群血清,经检测IgG抗体阳性78份,总阳性率为8.11%,其中隆德县IgG抗体阳性率最高(20.00%),其后依次为原州区(13.34%)、泾源县(7.95%)、西吉县(7.50%)和彭阳县(0.67%),海原县最低(0),不同县区间一般人群流行性出血热IgG抗体阳性率差异具有统计学意义;人群分布以农民和>50岁人群抗体阳性率较高,不同性别、不同职业以及不同文化程度之间抗体阳性率差异无统计学意义(P>0.05),但是不同年龄间抗体阳性率差异具有统计学意义(P<0.05),既往罹患流行性出血热或已接种过疫苗者抗体阳性率高于未患病或未接种疫苗者,且疫苗接种人群随着接种时间的延长,抗体阳性率呈下降趋势。结论 我区流行性出血热自然疫源地人群抗免疫水平较低,未形成有效屏障,存在疫情暴发流行的风险。建议加强开展爱国卫生运动和居家环境卫生整治,大力开展健康宣教,实施防鼠灭鼠和有计划、分步骤开展易感人群疫苗接种等综合性防控措施,提高居民疾病预防能力和疫苗接种覆盖率和依从性,构建免疫屏障,进一步降低疫情发生风险,保障疫区人民健康。
Objective natural foci of Ningxia, and to understand the general population′s immune level.Methods jurisdiction of 6 districts which are natural foci of epidemic hemorrhagic fever and have been reported epidemic hemorrhagic fever cases in recent years in Ningxia. We sampled 36 villages in these regions by stratified cluster random sampling method,twenty-five people were randomly selected from each village and collected 4 mL of venous blood for each person, and used enzyme-linked immunosorbent assay(ELISA) to detect epidemic hemorrhagic fever serum IgG antibodies.ResultsA total of962 sera from the general population were collected in this survey, of which 78 were IgG antibody positive after detection and the total positive rate was 8.11%. And the IgG antibody positive rate in Longde county was the highest(20.00%), followed by Yuanzhou county was 13.34%, Jingyuan county was 7.95%, Xiji county was 7.50%, Pengyang county was 0.67%, the IgG antibody positive rate in Haiyuan county was the lowest(0). The positive rate of IgG antibody of epidemic hemorrhagic fever in general population of different counties was statistically significant. There was no significant difference in antibody positive rate among different genders, occupations and educational levels. However, the difference in antibody positive rate between different ages was statistically significant. The antibody-positive rate of people who have suffered from epidemic hemorrhagic fever is higher than those who are not sick, and those who have been vaccinated is higher than people who have not been vaccinated.With the passage of time, the positive rate of antibody in vaccinated population decreased.Conclusions natural foci of epidemic hemorrhagic fever in Ningxia have a low level of immune status, and an effective immune barrier has not been formed, which may cause an outbreak. Therefore, it is recommended to further launch patriotic health campaigns and improve the home environment. In addition, it is necessary to prevent rodent damage, carry out health educ
作者
李涛
龚瑞
李海军
张生
段军
马学平
马莹
LI Tao;GONG Rui;LI Hai-jun;ZHANG Sheng;DUAN Jun;MA Xue-ping;MA Ying(Ningxia Center for Disease Control and Prevention,Yinchuan,Ningxia 750004,China;Guyuan Center for Disease Control and Prevention,Yuanzhouqu,Ningxia 756000,China;Zhongwei Center for Disease Control and Prevention,Shapotouqu,Ningxia 755000,China)
出处
《中国热带医学》
CAS
2022年第3期270-273,共4页
China Tropical Medicine
关键词
流行性出血热
抗体水平
一般人群
Epidemic hemorrhagic fever
antibody
general population
