摘要
害虫抗药性的发生发展和高风险杀虫剂的相继限用禁用致使市场上实际可用杀虫剂减少。作为源自蜘蛛毒肽的新型生物杀虫剂,GS-ω/κ-HXTX-Hv1a有望为持续有效的害虫治理提供新工具,其成功开发和应用有力证实了多肽可直接作为农药进行商业化。GS-ω/κ-HXTX-Hv1a具有经济实用的生产成本、独特的抑制剂胱氨酸结基序、协同的双重作用机制、全新的作用靶标位点、广谱的生物活性以及优异的安全性等特点,兼具化学杀虫剂的有效性和生物制品的低风险性,在害虫绿色防控、昆虫病原体改良、转基因作物开发和新农药创制等方面的应用前景广阔。从研发背景、通用名、序列结构、作用机制、生物活性、安全性和应用前景等方面对GS-ω/κ-HXTX-Hv1a研究开发与应用的进展情况进行总结,为GS-ω/κ-HXTX-Hv1a及同类蜘蛛毒肽品种在害虫防控上的研究、开发和应用提供参考和支持。
The occurrence and development of pest resistance and the successive restrictions and bans of high-risk insecticides have resulted in fewer insecticides actually available on the market.As a new biological insecticide derived from spider toxin peptide,GS-omega/kappa-HXTX-Hv1a is expected to provide a new tool for sustainable and effective insect pest management.Its successful development and application strongly demonstrate that polypeptides can be directly used as pesticides for commercialization.Possessing the characteristics like economical and practical production cost,unique inhibitor cystine knot(ICK)sequence motif,synergistic dual action mechanism,new target site,broad-spectrum biological activity and excellent safety profile,GS-omega/kappa-HXTX-Hv1a combines the effectiveness of chemical pesticides and the low-toxicity of biological products and hereby has bright application prospects in green insect pest control,entomopathogen improvement,genetically modified crops development and new pesticide discovery and etc.In this paper,progress of research,development and application of GS-omega/kappa-HXTX-Hv1a were reviewed from the aspects of research and development background,common name,sequence structure,mechanism of action,biological activity,safety and application prospects,in order to provide a reference and support on the research,development and application of GS-omega/kappa-HXTX-Hv1a and other spider toxin peptides in insect pest control.
作者
谭海军
童益利
TAN Haijun;TONG Yili(Suzhou ACE Chemical Technology Co.,Ltd.,Kunshan 215300,China;Jiangsu Rotam Chemistry Co.,Ltd.,Kunshan 215300,China)
出处
《世界农药》
CAS
2022年第7期29-40,60,共13页
World Pesticide
