摘要
【目的】探究大剂量羟考酮缓释片在晚期消化系统肿瘤中重度疼痛患者中的应用效果。【方法】对2017年1月至2020年4月西安市第四医院收治的60例晚期消化系统肿瘤中重度疼痛患者的临床资料进行回顾性分析。根据镇痛方案不同分为对照组和观察组,对照组患者给予常规剂量羟考酮缓释片(起始剂量为10mg/次)治疗,观察组患者给予大剂量羟考酮缓释片(起始剂量为40mg/次)治疗。比较两组患者的疼痛程度(疼痛数字评分法,NRS)、免疫功能[T细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))和自然杀伤细胞(NK)]、焦虑、抑郁(焦虑/抑郁自评量表评分,SAS/SDS)、应对方式(医学应对问卷,MCMQ)等指标的变化及不良反应发生情况。【结果】治疗前,两组患者NRS评分、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK细胞水平、SAS、SDS评分、MCMQ中屈服、逃避、面对评分比较,均无统计学意义(P>0.05);治疗后,两组患者NRS评分,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平,SAS、SDS评分,屈服、逃避评分均显著低于治疗前(P<0.05);CD8^(+)水平显著高于治疗前,且观察组患者治疗后NRS评分,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平,SAS、SDS评分,屈服、逃避评分显著低于对照组(P<0.05),CD8^(+)水平高于对照组(P<0.05)。【结论】大剂量羟考酮缓释片可有效缓解晚期消化系统肿瘤中重度疼痛患者的疼痛,增强免疫功能,降低焦虑、抑郁程度,且安全性不受影响。
【Objective】To explore the application effect of high-dose oxycodone sustained-release tablets in moderate and severe pain in patients with advanced digestive system tumors.【Methods】The clinical data of 60 patients with moderate and severe pain of advanced digestive system tumors treated in the oncology department of Xi'an Fouth Hospital from January 2017 to April 2020 were analyzed retrospectively.The patients in the control group were treated with conventional dose of oxycodone sustained-release tablets(the initial dose was 10 mg/therapy),and the patients in the observation group were treated with high-dose oxycodone sustained-release tablets(the initial dose was 40 mg/therapy).The changes of pain degree(NRS),immune function[T cell subsets(CD3^(+),CD4^(+),CD8^(+))and natural killer cells(NK)],anxiety and depression(SAS/SDS),coping style(Medical Coping Questionnaire,MCMQ)and adverse reactions were compared between the two groups.【Results】Before treatment,there was no significant difference in NRS score,CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),NK cell level,SAS,SDS score,yield,escape and face score in MCMQ between the two groups(P>0.05);After treatment,the NRS scores,CD3^(+),CD4^(+),CD4^(+)/CD8^(+),NK cell levels,SAS,SDS scores,yield and escape scores of the two groups were significantly lower than those before treatment(P<0.05);The level of CD8^(+)was significantly higher than that before treatment,and the NRS score,CD3^(+),CD4^(+),CD4^(+)/CD8^(+),NK cell level,SAS,SDS score,yield and escape score of the observation group were significantly lower than those of the control group(P<0.05),and the level of CD8^(+)was higher than that of the control group(P<0.05).【Conclusion】High dose oxycodone sustained release tablets can effectively alleviate the pain of patients with moderate and severe pain in advanced digestive system tumors,enhance immune function,reduce the degree of anxiety and depression,and the safety is not affected.
作者
郭争社
何印斌
GUO Zheng-she;HE Yin-bin(Department of Anesthesiology,Xi'an Honghui Hospital,Xi'an Shaanxi 710000)
出处
《医学临床研究》
CAS
2022年第6期913-916,920,共5页
Journal of Clinical Research
