摘要
目的分析CEA、CYFRA21在非小细胞肺癌患者血清中表达水平及与MSCT联合诊断价值。方法回顾性收集本院2016年6月至2019年1月收治的71例NSCLC患者的临床及影像学资料,另选取同时期良性肺疾病患者62例为良性疾病组。总结MSCT图像特征,对比不同人群中CEA、CYFRA21水平表达差异,计算不同检查对NSCLC的诊断效能。结果(1)NSCLC患者CEA、CYFRA21水平及其表达阳性率明显高于良性疾病组(P<0.001);(2)71例NSCLC患者患者中,34例患者肿块轮廓均出现不同程度的分叶,边缘可见“短毛刺”征,肿块最大径5.36cm,最小径0.67cm,平均直径(3.56±1.29)cm。71例患者中,邻近或远处淋巴结转移者有36例,病灶处累及胸膜者或脂肪线消失者19例。(3)CEA+CYFRA21+MSCT对NSCLC的诊断灵敏度、准确度分别为95.77%(68/71)、97.18%(69/71),明显优于单一标记物、MSCT及标记物联合检测(P<0.05)。结论MSCT联合CEA、CYFRA21检测可有效提高对NSCLC的诊断灵敏度、准确度。
Objective To analyze the expression levels of CEA and CYFRA21 in the serum of patients with nonsmall cell lung cancer and the diagnostic value of it combined with MSCT.Methods The clinical and imaging data of 71 patients with NSCLC treated in our hospital from June 2016 to January 2019 were retrospectively collected.Another 62 patients with benign lung disease at the same time were selected as the benign disease group.The characteristics of MSCT images were summarized,and the expression of CEA and CYFRA21 in different people were compared,and the diagnostic efficacy of different tests for NSCLC was calculated.Results(1)The levels of CEA and CYFRA21 and their positive expression rates in NSCLC patients were significantly higher than those in the benign disease group(P<0.001).(2)In the 71 patients with NSCLC,contours of the masses in the 34 patients showed various degrees of lobulation,and"short burr"signs were seen in the edges.The maximum diameter of the mass was 5.36cm,the minimum diameter was 0.67cm,and the average diameter was(3.56±1.29)cm.In the 71 patients,there were 36 cases with adjacent or distant lymph node metastasis,and 19 cases whose lesions involved the pleura or fat line disappeared.(3)The diagnostic sensitivity and accuracy of CEA+CYFRA21+MSCT for NSCLC were 95.77%(68/71)and 97.18%(69/71),which were significantly better than those of the single marker,MSCT and the combination of 3 markers(P<0.05).Conclusion MSCT combined with CEA and CYFRA21 detection can effectively improve the diagnostic sensitivity and accuracy for NSCLC.
作者
刘曾维
陈璧颖
钟鹏
方伟军
黎惠如
LIU Zeng-wei;CHEN Bi-ying;ZHONG Peng;FANG Wei-jun;LI Hui-ru(Department of Radiology,Guangzhou Chest Hospital,Guangzhou 510095,Guangdong Province,China)
出处
《中国CT和MRI杂志》
2022年第8期62-64,共3页
Chinese Journal of CT and MRI
基金
广东省医学科学技术研究基金(B2017279)。
