摘要
类淋巴系统是一个功能性脑脊液循环系统, 主要发挥脑实质内代谢废物的清除功能, 是脑科学领域研究的热点。类淋巴系统功能障碍与多种神经退行性疾病的发生密切相关。在基础研究领域, 麻醉是活体动物进行类淋巴系统神经影像学研究的前提, 然而麻醉药物能否影响类淋巴系统功能还存在争议。文章对应用于类淋巴系统研究中的麻醉药物进行综述, 分析干扰类淋巴系统功能的各项生理因素, 讨论不同麻醉方案对类淋巴系统功能的影响, 为后续进行类淋巴系统研究的麻醉药物选择及结果解读提供参考。
The glymphatic system is a functional cerebrospinal fluid circulatory system.The primary function of glymphatic transport is clearance of metabolic waste,it is a hot spot in the field of brain science research in recent years.Several studies have re‑ported that glymphatic system dysfunction is implicated in multiple neurodegenerative disorders.Anesthesia is a prerequisite to study the glymphatic system using neuro‑imaging method.However,whether anesthesia alters glymphatic system function remains controver‑sial.This study will generate a comprehensive review of anesthetic drugs that have been used in glymphatic system research,analyze the physiological factors that interfere with the function of glymphatic system,and discuss the influence of different anesthetic regimens on the function of the glymphatic system.This study provides a reference for the choice of anesthetic agents and interpretation of the re‑sults in the study of glymphatic system.
作者
董瑞
韩玉强
张富俊
夏天娇
顾小萍
Dong Rui;Han Yuqiang;Zhang Fujun;Xia Tianjiao;Gu Xiaoping(Department of Anesthesiology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China;Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University,Nanjing 210008,China;Nanjing Drum Tower Hospital Clinical College of Jiangsu University,Nanjing 210008,China;Jiangsu Key Laboratory of Molecular Medicine,Nanjing 210093,China)
出处
《国际麻醉学与复苏杂志》
CAS
2022年第4期435-440,共6页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81730033, 81701371, 82001132)
十三五强卫工程重点人才项目(ZDRCA2016069)
南京大学医学院研究生科研与实践创新计划项目(2021)。
关键词
类淋巴系统
麻醉药物
生理
Glymphatic system
Anesthetic drugs
Physiology
