摘要
目的探究集成磁共振成像(synthetic magnetic resonance imaging,SyMRI)技术对轻微型肝性脑病(minimal hepatic encephalopathy,MHE)患者脑实质内特定区域弛豫值、质子密度(proton density,PD)值定量检测的价值。材料与方法前瞻性纳入2020年8月至2021年11月在宁夏医科大学总医院感染疾病科经临床诊断为肝硬化的住院患者并根据神经精神量表筛选出MHE患者23名为MHE组。同期招募年龄、性别及受教育程度等相匹配的健康志愿者20名为健康对照(healthy control,HC)组。所有受试者均在3.0 T MRI扫描仪上行SyMRI扫描,选取双侧尾状核、壳核、苍白球、背侧丘脑及额叶白质为感兴趣区(region of interest,ROI),并分别测量T1、T2及PD值。采用组内相关系数(intraclass correlation coefficient,ICC)评价观察者间数据测量的一致性,采用Mann-Whitney U秩和检验对MHE组及HC组T1、T2及PD值进行比较并统计其在两组间的差异及诊断效能。结果两名医师对脑实质各ROI的T1、T2及PD值测量的一致性较好,ICC值分别为0.863、0.822、0.816。除双侧额叶白质外,MHE组较HC组部分亚区T1、T2及PD值降低,差异具有统计学意义(P<0.05)。T1值中双侧壳核、右侧苍白球在MHE组及HC组间差异具有统计学意义;T2值中右侧尾状核、双侧壳核及左侧苍白球在MHE组及HC组间差异具有统计学意义;PD值中右侧壳核在MHE组及HC组间差异具有统计学意义。与HC组相比,MHE组双侧额叶T1值及PD值升高,差异具有统计学意义(P<0.05)。右侧额叶的PD值诊断效能最高,受试者工作特征曲线下面积为0.901。结论SyMRI对MHE患者各脑区弛豫值具有较好的定量能力,其T1、T2及PD值在检出MHE患者中有一定的潜在价值。
Objective:To investigate the value of the synthetic magnetic resonance imaging(Sy MRI) technique for the quantitative detection of relaxation values and proton density(PD) values in specific regions within the brain parenchyma of minimal hepatic encephalopathy(MHE)patients.Materials and Methods:Twenty-three patients with MHE were collected from August 2020 to November 2021 from inpatients clinically diagnosed with cirrhosis at the Department of Infectious Diseases,General Hospital of Ningxia Medical University and screened according to the neuropsychiatric inventory.During the same period,20 healthy volunteers with comparable matches for age,gender and education were collected.All subjects underwent Sy MRI scans on a 3.0 T MRI scanner,and caudate nucleus,putamen,globus pallidus,thalamus and frontal white matter were selected as region of interest(ROIs),and T1,T2 and PD values were measured.The intraclass correlation coefficient(ICC) was used to evaluate the interobserver agreement of data measurements,and the Mann-Whitney U test was used to compare the T1,T2 and PD values between the MHE and healthy control(HC) groups and to count the differences between the MHE-HC groups and their diagnostic efficacy.Results:There was good agreement between the two physicians on the measurement of T1,T2 and PD values for each ROI of the brain parenchyma,with ICC values of 0.863,0.822 and 0.816,respectively.Except for the bilateral frontal white matter,the T1,T2,and PD values of some subregions in the MHE group were lower than those in the HC group,and the differences were statistically significant(P<0.05).The T1 values of bilateral putamen and right globus pallidus were statistically significant between the MHE and HC groups;the T2 values of the right caudate nucleus,bilateral putamen and left globus pallidus were statistically significant between the MHE and HC groups;the PD values of right putamen were statistically significant between the MHE and HC groups.Compared with the HC group,the T1 and PD values of bilateral frontal w
作者
刘文潇
党佩
杨旭宏
王明磊
赵建国
葛鑫
吕瑞瑞
雍鹏
王晓东
LIU Wenxiao;DANG Pei;YANG Xuhong;WANG Minglei;ZHAO Jianguo;GE Xin;LÜ Ruirui;YONG Peng;WANG Xiaodong(School of Clinical Medicine,Ningxia Medical University,Yinchuan 750001,China;Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750001,China;Key Laboratory of Craniocerebral Diseases of Ningxia Medical University,Yinchuan 750001,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第5期6-10,16,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
宁夏回族自治区科技重点研究计划(编号:2019BEG03037)
宁夏医科大学颅脑疾病重点实验室神经科学优势学科群(编号:LNKF202109)
2022年度宁夏回族自治区自然科学基金项目(编号:2022AAC03487)。
关键词
轻微型肝性脑病
集成磁共振成像
质子密度
弛豫值
诊断效能
minimal hepatic encephalopathy
synthetic magnetic resonance imaging
proton density
relaxometry
diagnostic efficacy
