摘要
目的:评价口服独活寄生汤治疗经皮内窥镜下腰椎间盘切除术(percutaneous endoscopic lumbar discectomy,PELD)后残余症状的临床疗效。方法:应用计算机检索中国知网、维普网、万方数据库、中国生物医学文献服务系统、PubMed、Embase、Cochrane Library和WebofScience中关于口服独活寄生汤治疗PELD术后残余症状的随机对照试验文献,检索时限为建库至2021年7月1日。试验组采用口服独活寄生汤治疗,也可联合口服抗生素、口服甲钴胺或常规康复治疗;对照组采用口服抗生素、口服甲钴胺或常规康复治疗。由2名研究者独立检索、筛选文献,提取资料,并采用Cochrane偏倚风险评估工具对纳入文献的质量及偏倚风险进行评估。采用RevMan5.3软件进行Meta分析。结果:共检索出49篇相关文献,通过逐层筛选,最终纳入8篇文献,均为中文文献,共涉及700例患者,其中试验组351例、对照组349例。Meta分析结果显示,试验组患者腰腿部疼痛视觉模拟量表评分、腰椎Oswestry功能障碍指数评分均低于对照组[MD=-0.77,95%CI(-0.94,-0.59),P=0.000;MD=-7.98,95%CI(-9.10,-6.86),P=0.000],试验组患者日本骨科协会腰痛疾患疗效评分、尼龙绳试验评分均高于对照组[MD=3.51,95%CI(2.74,4.28),P=0.000;MD=1.96,95%CI(1.64,2.28),P=0.000]。结论:现有的证据表明,口服独活寄生汤可以缓解PELD术后的腰腿部疼痛及下肢麻木、无力等症状,改善腰椎功能。
Objective:To evaluate the clinical outcomes of oral application of Duhuo Jisheng Tang(独活寄生汤,DHJST)for treatment of residual symptoms emerged after percutaneous endoscopic lumbar discectomy(PELD).Methods:All the randomized controlled trial(RCT)articles about oral application of DHJST for treatment of residual symptoms emerged ater PELD included from database establishing to July 1,2021 were retrieved from the China National Knowledge Internet,Vip Database,Wanfang Database,Chinese Biomedical Literature Service System,PubMed,Embase,Cochrane Library and Web of Science through computer.The patients in experimental group were treated with oral application of DHJST,or combined with oral application of antibiotics,oral application of mecobalamine or conventional rehabilitation therapy;while the ones in control group with oral application of antibiotics,oral application of mecobalamine or conventional rehabilitation therapy alone.The articles were retrieved and screened and the information was extracted independently by two researchers according to the inclusion and exclusion criteria,and if any disagreement was found between them,discussion was conducted or asked for another researcher for making a final decision.The methodological quality and bias risk of research in the articles was evaluated by using Cochrane bias risk assessment tools,and then a Meta-analysis was conducted by using RevMan5.3 software.Results:Forty-nine articles were searched out.After screening,8 Chinese articles(700 patients)were included in the final analysis,351 patients in experimental group and 349 ones in control group.The results of Meta-analysis revealed that the lumbago-leg pain visual analogue scale(VAS)scores and lumbar Oswestry disability index(ODI)scores were lower,while the Japanese Orthopaedic Association(JOA)low back pain efficacy scores and Nylon rope test scores were higher in experimental group compared to control group(MD=-0.77,95%CI(-0.94,-0.59)=0.000;MD=-7.98,95%CI(-9.10,-6.86),P=0.000;MD=3.51,95%CI(2.74,4.28),P=0.000;
作者
杨焕莹
王想福
赵道洲
李晨旭
张万乾
陈伟国
桑廷瑞
张超
丁艳芳
张晶博
YANG Huanying;WANG Xiangfu;ZHAO Daozhou;LI Chenxu;ZHANG Wanqian;CHEN Weiguo;SANG Ting-rui;ZHANG Chao;DING Yanfang;ZHANG Jingbo(Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Gansu Provincial Hospital of TCM,Lanzhou 730050,Gansu,China)
出处
《中医正骨》
2022年第7期34-39,共6页
The Journal of Traditional Chinese Orthopedics and Traumatology
基金
甘肃省科技计划项目(21JR1RA058)
兰州市人才创新创业项目(2020-RC-54)
关键词
椎间盘移位
腰椎
独活寄生汤
椎间盘切除术
经皮
术后残余症状
专题Meta分析
intervertebral disc displacement
lumbar vertebrae
Duhuo Jisheng decoction
diskectomy,percutaneous
postoperative residual symptoms
meta-analysis as topic
