摘要
调查我国神经外科医师对动脉瘤性蛛网膜下腔出血后预防痫性发作的认知和决策现况。设计《动脉瘤性蛛网膜下腔出血预防性使用抗癫痫药物的问卷》,通过“问卷星”网络平台进行数据采集。2021年7至10月,共收集有效问卷82份,符合纳入标准的有43份。受访者来自32个省、市、自治区年收治动脉瘤性蛛网膜下腔出血100例以上的医学院附属医院。仅有9.3%(4/43)的受访者不认同预防用药,86.04%(37/43)的受访医师在临床实践中进行预防性用药,丙戊酸钠(94.59%,35/37)是最常用的预防药物。各中心预防性用药的时长从<3 d至>14 d不等,具有很大差异。脑电图的应用率、我国神经外科医师临床观察到的痫性发作比例均较低。调查结果提示,目前我国动脉瘤性蛛网膜下腔出血后预防痫性发作的临床实践尚不够规范,临床医师对相关知识的掌握仍不够全面。开展高质量临床研究将有利于明确预防用药的必要性,并对规范用药产生积极影响。
To investigate the current status of cognition and decision-making on seizure prophylaxis after aneurysmal subarachnoid hemorrhage in Chinese neurosurgeons.A questionnaire for this theme was designed and sent to respondents through the"Questionnaire Star"network platform.From July to October 2021,a total of 43 eligible questionnaires were collected.All respondents came from affiliated hospitals of medical schools across China.Each of these hospitals treated more than one hundred patients with aneurysmal subarachnoid hemorrhage per year.Only 9.3%(4/43)of respondents disagreed with the prophylactic use of anticonvulsants.However,86.04%(37/43)of respondents performed seizure prophylaxis in clinical practice.Sodium valproate was the most commonly used regimen,and 94.59%(35/37)of respondents used this drug.The medication period differed sharply among different hospitals,from less than 3 days to longer than 14 days.The use of electroencephalography(EEG)was insufficient in Chinese patients,and a low seizure rate was reported according to the feedback from Chinese neurosurgeons.To date,seizure prophylaxis after subarachnoid hemorrhage was not yet standardized in China,and clinicians′mastery of relevant knowledge is still not enough.Therefore,carrying out high-quality clinical research can help clarify the use of anticonvulsants,which could also positively impact rational drug use.
作者
陈雨麒
田蕊
徐伟
方美
吴虹刚
彭建华
谢之易
吴培
马潞
游潮
胡鑫
Chen Yuqi;Tian Rui;Xu Wei;Fang Mei;Wu Honggang;Peng Jianhua;Xie Zhiyi;Wu Pei;Ma Lu;You Chao;Hu Xin(West China School of Medicine,Sichuan University,Chengdu 610041,China;Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Neurosurgery,People′s Hospital of Leshan,Leshan 614000,China;Department of Neurosurgery,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Department of Neurosurgery,the Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Neurosurgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第25期1931-1934,共4页
National Medical Journal of China
基金
四川省卫生健康委员会医学科技项目(21PJ034)
四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目(2021HXFH045)。
关键词
蛛网膜下腔出血
发作
化学预防
临床决策
调查和问卷
Subarachnoid hemorrhage
Seizures
Chemoprevention
Clinical decision‑making
Surveys and questionnaires
