摘要
经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOSES患者数据,进一步探讨NOSES的短期疗效与预后.研究对象中,经直肠NOSES占整体比例的90.3%,经阴道NOSES占9.7%.NOSES术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOSES具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据.
作者
Xu Guan
Xiyue Hu
Zheng Jiang
Ye Wei
Donghui Sun
Miao Wu
Haitao Zhou
Hongliang Yao
Junmin Song
Guiyu Wang
Junhong Hu
Mingyang Ren
Qing Xu
Jianchun Cai
Jian Peng
Dan Ma
Yangchun Zheng
Qingsi He
Bo Jiang
Zejun Wang
Taiyuan Li
Su Yan
Luchuan Chen
Tiegang Li
Zhiguo Xiong
Pan Chi
Liang Kang
Gang Yu
Xiaodong Deng
Hong Zhang
Ming Xie
Jianbao Wei
Hongyan Gong
Xuejun Sun
Weidong Zang
Yongmao Song
Peng He
Zhengqi Wen
Chunxu Zhang
Yusheng Wang
Yinggang Chen
Guangwei Xie
Mingzhang Li
Shaojun Yu
Haiying Liu
Min Pu
Chuangang Fu
Xishan Wang
on behalf of China NOSES Alliance
关旭;胡茜玥;姜争;韦烨;孙东辉;吴淼;周海涛;姚宏亮;宋军民;王贵玉;胡军红;任明扬;徐庆;蔡建春;彭健;马丹;郑阳春;何庆泗;江波;王泽军;李太原;燕速;陈路川;李铁钢;熊治国;池畔;康亮;于刚;邓小东;张宏;谢铭;韦建宝;宫红彦;孙学军;臧卫东;宋永茂;赫鹏;文政琦;张春旭;王昱晟;陈瑛罡;谢光伟;李明章;俞少俊;刘海鹰;蒲敏;傅传刚;王锡山;中国经自然腔道取标本手术联盟(Department of Colorectal Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Gastrointestinal and Anal Surgery,Jilin University First Hospital,Changchun 130021,China;Department of Gastrointestinal Surgery,The Second People’s Hospital of Yibin,Yibin 644000,China;Department of Gastrointestinal Surgery,The Second Xiangya Hospital,Central South University,Changsha 410011,China;Department of Anorectal Surgery,First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Department of Colorectal Cancer Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China;Department of Gastrointestinal Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Department of Gastrointestinal Surgery,Renji Hospital,Shanghai JiaoTong University School of Medicine,Shanghai 200240,China;Department of Gastrointestinal Surgery,Zhongshan Hospital of Xiamen University,Xiamen 361004,China;Department of General Surgery,Xiangya Hospital,Central South University,Changsha 410008,China;Department of General Surgery,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;Department of Gastrointestinal Surgery,Sichuan Cancer Hospital,Chengdu 610041,China;Department of General Surgery,Shandong University Qilu Hospital,Jinan 250012,China;Department of Colorectal and Anal Surge
基金
supported by the Beijing Municipal Science&Technology Commission(D171100002617004)。