摘要
目的探讨腹腔镜根治术对结直肠癌患者手术指标、炎性因子及术后并发症的影响。方法选取2017年5月—2021年3月收治的86例结直肠癌,根据手术方式的不同分为研究组(予腹腔镜根治术)和对照组(予传统开腹手术)各43例。对比2组手术指标,手术前后肿瘤标志物、炎性因子、免疫功能指标水平及术后并发症发生率。结果研究组术中出血量少于对照组,术后肛门排气天数及住院天数短于对照组(P<0.01)。术后7 d,2组癌胚抗原与癌抗原19-9水平降低,且研究组低于对照组(P<0.05,P<0.01)。术后7 d,2组C反应蛋白、白细胞介素-6及降钙素原水平均升高,且研究组升高程度低于对照组(P<0.05,P<0.01)。术后7 d,与对照组相比,研究组CD4+、CD4^(+)/CD8^(+)升高,CD8^(+)降低(P<0.01)。研究组术后并发症总发生率(6.98%,3/43)低于对照组(23.26%,10/43)(P<0.05)。结论腹腔镜根治术治疗结直肠癌效果显著,对于手术指标的优化具有促进作用,并有利于减轻炎症反应和免疫功能损伤,调节肿瘤标志物水平,且术后并发症少。
Objective To investigate the effects of laparoscopic radical surgery on surgical indicators,inflammatory factors and postoperative complications in patients with colorectal cancer(CRC).Methods A total of 86 patients with CRC treated from May 2017 to March 2021 were selected and divided into research group(laparoscopic radical surgery,n=43)and control group(traditional open surgery,n=43)according to different surgical methods.Surgical indexes,tumor markers,inflammatory factors,immune function indexes before and after operation and postoperative complications were compared between the two groups.Results The amount of blood loss during operation in the research group was less than that in the control group,and the days of postoperative anal exhaust and length of hospitalization were shorter in the research group than those in the control group(P<0.01).At 7 days after operation,the levels of carcinoembryonic antigen and carcinogenic antigen 19-9 in the two groups were decreased,and the levels in research group were lower than those in control group(P<0.05,P<0.01).At 7 days after operation,C reactive protein,interleukin-6 and calcitonin in the two groups were increased on average,and the degree of increase in the research group was lower than that in the control group(P<0.05,P<0.01).At 7 days after operation,CD4^(+),and CD4^(+)/CD8^(+)were increased and CD8+was decreased in the research group compared with the control group(P<0.01).The total incidence of postoperative complications in the research group(6.98%,3/43)was lower than that in the control group(23.26%,10/43)(P<0.05).Conclusion Laparoscopic radical surgery is effective in the treatment of CRC,which can promote the optimization of surgical indicators,reduce the inflammatory response and immune function damage,adjust the level of tumor markers,and have fewer postoperative complications.
作者
姜远远
曾春辉
韩帅
翁莉
JIANG Yuanyuan;ZENG Chunhui;HAN Shuai;WENG Li(Department of Gastrointestinal Surgery,the First People's Hospital of Suzhou City,Suzhou,Anhui 234000,China;Department of Interventional Medicine,Shanghai Tongren Hospital,Shanghai 020000,China)
出处
《转化医学杂志》
2023年第4期155-158,共4页
Translational Medicine Journal
基金
长宁区科学技术委员会课题(CNKW2020Y13)。
关键词
结直肠肿瘤
腹腔镜根治术
术中出血量
癌胚抗原
C反应蛋白
CD4+
CD8+
手术后并发症
Colorectal neoplasms
Laparoscopic radical surgery
Intraoperative blood loss
Carcinoembryonic antigen
C reactive protein
CD4+
CD8+
Postoperative complications
