摘要
目的 研究胆总管结石继发急性胆管炎的患者采用血清CA199联合降钙素原检测方式对病情进行诊断的临床价值。方法 选择在茂名市电白区人民医院2017年10月-2019年10月治疗的单纯胆总管结石和胆总管结石继发急性胆管炎的确诊患者各40例,同时再抽取同期在我院接受健康体检的同年龄段健康人资料40例,分别将其定义为研究1组、研究2组、对照组。采用干式免疫荧光定量法、电化学发光法、免疫散射比浊法对三组研究对象的血清降钙素原、血清CA199、C反应蛋白等三项指标水平进行测定。对比三组研究对象肝功能和炎症反应相关指标水平、上述指标检测结果及阳性率。结果 研究2组研究对象血清降钙素原、血清CA199、C反应蛋白水平高于研究1组,组间差异有统计学意义(P<0.05);研究1组三项指标水平高于对照组,组间差异有统计学意义(P<0.05)。研究2组研究对象血清降钙素原、血清CA199、C反应蛋白水平检测结果阳性率高于研究1组,组间差异有统计学意义(P<0.05);研究1组三项指标水平检测结果阳性率高于对照组,组间差异有统计学意义(P<0.05)。结论 胆总管结石继发急性胆管炎的患者的血清CA199、降钙素原、C反应蛋白水平会明显异于单纯胆总管结石患者及健康人群,临床上可以将这一特征,作为对该类患者病情进行诊断和对治疗效果进行评价的重要参考指标,使诊断准确性提高,为患者争取更多的有效治疗时间。
Objective To study clinical value of serum CA199 combined with procalcitonin in diagnosis of acute cholangitis secondary to common bile duct stones.Methods The paper chose 40 patients with simple choledocholithiasis and 40 patients with acute cholangitis secondary to choledocholithiasis treated in our hospital from October 2017 to October 2019,and 40 healthy people at same age with physical examination in our hospital during the same period as study group 1,study group 2 and control group respectively.Levels of serum procalcitonin,serum CA199 and C-reactive protein were measured by dry immunofluorescence quantitative method,electrochemiluminescence method and immune scattering turbidimetry.Levels of indicators related to liver function and inflammatory response,test results and positive rates of above indicators were compared among three groups.Results Levels of serum procalcitonin,serum CA199 and C-reactive protein in study group 2 were higher than group 1,difference between groups was statistically significant (P<0.05);levels of three indexes in study group 1 were higher than control group,difference between groups was statistically significant (P<0.05).Positive rates of serum procalcitonin,serum CA199 and C-reactive protein levels in study group 2 were higher than group 1,difference between groups was statistically significant,(P<0.05);positive rate of three indexes in study group 1 was higher than control group,difference between groups was statistically significant (P<0.05).Conclusion Levels of serum CA199,procalcitonin and C-reactive protein in patients with choledocholithiasis secondary to acute cholangitis are significantly different from patients with simple choledocholithiasis and healthy people.Clinically,the feature can be used as an important reference index for diagnosis of patients and evaluation of treatment effect,to improve accuracy of diagnosis and strive for more effective treatment time for patients.
作者
林美姬
郑乐
LIN Meiji;ZHENG Le(Maoming City Dianbai District People's Hospital,Maoming,Guangdong,552400)
出处
《智慧健康》
2022年第9期10-12,共3页
Smart Healthcare
