摘要
目的:分析烧伤整形科烧伤患者病原菌分布特点及耐药性状况的流行病学资料,以指导临床合理使用抗生素。方法:选择2016年1月-2020年6月在吉安市中心人民医院烧伤整形科接受治疗的1913例烧伤患者的临床标本(创面分泌物、血液、导管等),共获取506株菌株,分析菌株分布特点及各种菌株的耐药情况。结果:506株菌株中,革兰阴性菌221株占43.68%,主要为铜绿假单胞菌、阴沟肠杆菌、肺炎克雷伯菌、大肠埃希菌、鲍曼不动杆菌;革兰阳性菌283株占55.93%,主要为金黄色葡萄球菌、溶血葡萄球菌、表皮葡萄球菌、粪肠球菌、中间葡萄球菌;真菌2株占0.40%,为热带假丝酵母菌及近平滑假丝酵母菌。金黄色葡萄球菌检出率最高,共126株占24.90%,其次是铜绿假单胞菌和溶血葡萄球菌,依次为49株占9.68%、43株占8.50%。对革兰阴性菌和革兰阳性菌中主要的五种菌种耐药性分别进行分析,发现铜绿假单胞菌对阿米卡星、多粘菌素B、环丙沙星、美罗培南、庆大霉素、妥布霉素的耐药率均低于10%;阴沟肠杆菌阿米卡星、环丙沙星、左旋氧氟沙星药物耐药率均低于10%;肺炎克雷伯菌对阿米卡星、美罗培南、亚胺培南(泰能)、左氧氟沙星、厄他培南的耐药率均低于10%;大肠埃希菌对阿米卡星、氨曲南、美罗培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦(舒普深)、头孢西丁、亚胺培南(泰能)、厄他培南耐药率均低于10%;鲍曼不动杆菌对多粘菌素B、米诺环素耐药率均为0。金黄色葡萄球菌对利福平、利奈唑胺、万古霉素、替考拉宁、达托霉素的耐药率均低于5%;溶血葡萄球菌对利奈唑胺、万古霉素、替考拉宁、达托霉素的耐药率均为0;表皮葡萄球菌对利奈唑胺、万古霉素、替考拉宁、利福平的耐药率均低于5%;粪肠球菌对达托霉素、利奈唑胺、万古霉素、替考拉宁的耐药率均为0;中间葡萄球菌对�
Objective:To analyze the epidemiological data of pathogen distribution and drug resistance in burn patients in burn and plastic surgery department,so as to guide the rational use of antibiotics in clinic.Method:Clinical specimens(wound secretion,blood,catheter,etc.)from 1913 burn patients treated in the Department of Burn Orthopaedics,Ji’an Central People’s Hospital from January 2016 to June 2020 were selected,a total of 506 strains were collected and their distribution characteristics and drug resistance were analyzed.Result:Among the 506 strains,221 were Gram-negative bacteria,accounting for 43.68%,mainly Pseudomonas aeruginosa,Enterobacter cloacae,Klebsiella pneumoniae,Escherichia coli,and Acinetobacter baumannii;Gram-positive bacteria 283 strain accounted for 55.93%,mainly Staphylococcus aureus,Staphylococcus hemolyticus,Staphylococcus epidermidis,Enterococcus faecalis,Staphylococcus intermedius;2 fungi accounted for 0.40%,Candida tropicalis and Candida parapsilosis.The detection rate of Staphylococcus aureus was the highest,with a total of 126 isolates accounting for 24.90%,followed by Pseudomonas aeruginosa and Staphylococcus hemolyticus,followed by 49 isolates accounting for 9.68%and 43 isolates accounting for 8.50%.The drug resistance of five major strains of Gram-negative bacteria and Gram-positive bacteria was analyzed respectively,it was found that the drug resistance rates of Pseudomonas aeruginosa to Amikacin,Polymyxin B,Ciprofloxacin,Melopenem,Gentamicin,Tobramycin were all less than 10%;the drug resistance rates of Enterobacter cloacae Amikacin,Ciprofloxacin and Levofloxacin were all lower than 10%;the drug resistance rates of Klebsiella pneumoniae to Amikacin,Meropenem,Imipenem(Tylenone),Levofloxacin,Ertapenem were all less than 10%;the drug resistance rates of Escherichia Coli to Amikacin,Amtronam,Melopenem,Piperacillin/Tazobactam,Cefoperazone/Sulbactam(Supushen),Cefoxitin,Imipenem(Tylenone),Ertapenem were all less than 10%;the drug resistance rates of Acinetobacter baumannii to Polymyxin B a
作者
康群军
唐晶
胡安根
刘礼平
曾志刚
朱鹏
KANG Qunjun;TANG Jing;HU Angen;LIU Liping;ZENG Zhigang;ZHU Peng(Ji’an Central People’s Hospital,Jiangxi Province,Ji’an 343000,China;不详)
出处
《中国医学创新》
CAS
2022年第20期145-150,共6页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(20204839)。
关键词
烧伤
感染
病原菌
耐药性
流行病学
Burn
Bacterial infections
Pathogens
Drug resistance
Epidemiology
