摘要
目的探讨中文版Addenbrooke认知评估量表Ⅲ(Addenbrooke’s cognitive examination-Ⅲ,ACE-Ⅲ)在老年帕金森病(Parkinson’s disease,PD)患者轻度认知障碍中的应用价值及最佳临界值。方法于2020年1月—2021年5月在江苏省省级机关医院选取52例年龄≥60岁的PD患者,根据认知功能评估将其分为认知功能正常(NCI)组和轻度认知障碍(MCI)组。受试者使用蒙特利尔认知评估量表(MocA)和中文版ACE-Ⅲ量表进行认知功能评估和分析。结果中文版ACE-Ⅲ量表的Cronbach’s系数为0.609。中文版ACE-Ⅲ评分和MocA评分呈正相关(r=0.672,P<0.001),ACE-Ⅲ识别PD-MCI患者的受试者工作特征(ROC)曲线下面积为0.845(95%CI:0.726~0.963)。当ACE-Ⅲ诊断界值为87.5分时,约登指数0.602,此时灵敏度为0.786,特异度为0.816。MCI组在ACE-Ⅲ量表的注意/定向、记忆、语言等子维度评分上低于NCI组,差异具有统计学意义(P<0.05)。结论中文版ACE-Ⅲ量表检测帕金森病相关的MCI灵敏性和特异性较好,其结果可以分析相关MCI认知域(包括注意/定向、记忆、语言)受损的特点,有利于临床中对PD-MCI患者进行早期识别。
Objective To explore the application value and optimal critical value of Chinese version ofAddenbrooke’s Cognitive Examination-Ⅲ(ACE-Ⅲ)scale in mild cognitive impairment in elderly patients with Parkinson’s disease(PD).Methods From January 2020 to May 2021,52PD patients aged≥60 years were selected from Jiangsu Provincial Government Hospital.They were divided into normal cognitive function(NCI)group and mild cognitive impairment(MCI)group according to cognitive function assessment.The Montreal Cognitive Assessment Scale(MoCA)and the Chinese version of ACE-Ⅲscale were used to evaluate and analyze the cognitive function of the subjects.Results The Cronbach’sαcoefficient of Chinese version of ACE-Ⅲwas0.609.The Chinese version of ACE-Ⅲscore was positively correlated with MoCA score(R=0.672,P<0.001).The area under the receiver operating characteristic(ROC)curve of ACE-Ⅲin identifying PD-MCI patients was 0.845(95%CI:0.726-0.963).When the diagnostic critical value of ACE-Ⅲwas 87.5points,the Youdenindex was 0.602,the sensitivity was 0.786,and the specificity was 0.816.The scores of attention/orientation,memory,language and other sub-items of the ACE-Ⅲscale of the MCI group were lower than those of the NCI group,and the difference was statistically significant(P<0.05).Conclusion The Chinese version of the ACE-Ⅲscale has good sensitivity and specificityinidentifying Parkinson’s disease-related MCI,and the results can be used to analyze the characteristics of the impairment of related MCI cognitive domains(including attention/orientation,memory,language),which is beneficial to the early identification of PD-MCI patients in clinical practice.
作者
吴玉霞
莫永珍
郑慧芬
王变荣
刘欢
蒋承慧
薄莹莹
孙云
唐伟
Wu Yuxia;Mo Yongzhen;Zheng Huifen;Wang Bianrong;Liu Huan;Jiang Chenghui;Bo Yingying;Sun Yun;Tang Wei(School of Nursing,Medical College of Soochow University,Suzhou,Jiangsu,215006,P.R.China;Jiangsu Provincial Government Hospital,Nanjing,Jiangsu,210024,P.R.China;School of Nursing,Nanjing Medical University,Nanjing,Jiangsu,211166,P.R.China)
出处
《老年医学与保健》
CAS
2022年第3期525-529,534,共6页
Geriatrics & Health Care
关键词
帕金森病
老年
认知障碍
中文版ACE-Ⅲ
量表
筛查
Parkinson’s disease
elderly
cognitive impairment
Chinese version of ACE-Ⅲ
scale
screening
