摘要
全球范围内艾滋病(acquired immune deficiency syndrome,AIDS)/结核病(tuberculosis,TB)双重感染的发病率和检出率仍持续增高,HIV导致人体细胞免疫功能缺陷和体内的炎性细胞因子的分泌增加,罹患TB的风险大大增加。同时结核感染通过促进共受体CCR5与CXCR4的表达等机制,使HIV病毒感染巨噬细胞和T细胞。AIDS/TB双重感染患者的TB症状与免疫功能抑制水平有关,以Gene Xpert MTB/RIF为代表的新型分子生物学技术显示良好的病原学诊断价值。规范化临床治疗及预防、管理仍是实现AIDS/TB双重感染有效防控的重要策略。本文总结了AIDS/TB双重感染流行现状和诊疗、机制等方面的新进展。
In worldwide,the incidence rate and detection rate of acquired immune deficiency syndrome(AIDS)/tuberculosis(TB)double infection continues to increase.HIV leads to the defect of human cellular immune function and the increase of inflammatory cytokine secretion in the body,which greatly increases the risk of suffering from TB.At the same time,tuberculosis infection makes HIV virus infect macrophages and T cells by promoting the expression of co-receptors CCR5 and CXCR4.TB symptoms in patients with AIDS/TB co-infection are related to the level of immune function inhibition.The new molecular biology technology represented by Gene Xpert MTB/RIF shows high pathogenic diagnostic value.Standardized clinical treatment,prevention and management are still important strategies to achieve effective prevention and control of AIDS/TB double infection.This article summarizes the epidemic status of AIDS/TB double infection and the new progress in diagnosis and treatment and mechanism and other aspects.
作者
李雨薇
李侠
LI Yuwei;LI Xia(Dali University,Dali 671000,China;不详)
出处
《中外医学研究》
2022年第16期181-184,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
云南省科技厅科技计划项目(2018ZX10715006-003)
国家卫生健康委员会毒品依赖和戒治重点实验室科学研究项目(2020DAMOP-0012)。
关键词
结核病
艾滋病
研究进展
Tuberculosis
AIDS
Research progress
