摘要
目的:探究多点注射亚甲蓝联合超声在乳腺癌前哨淋巴结活检术中的应用价值。方法:选取福建医科大学附属龙岩第一医院2020年1月-2021年1月实施前哨淋巴结活检术的100例乳腺癌患者。根据其乳腺癌前哨淋巴结活检术中是否应用超声进行分组,其中50例术中多点注射亚甲蓝联合超声为试验组,50例单点注射亚甲蓝为对照组。观察两组前哨淋巴结检出情况。以病理结果为金标准,分析两种方法的诊断结果,比较两种方法对前哨淋巴结诊断效能,包括敏感度、特异度、准确度、阳性预测值、阴性预测值。结果:两组前哨淋巴结检出率比较差异无统计学意义(P>0.05)。多点注射亚甲蓝联合超声对前哨淋巴结诊断的敏感度为93.62%,特异度为91.76%,准确度为92.42%,阳性预测值为86.27%,阴性预测值为96.30%。单点注射亚甲蓝对乳腺前哨淋巴结诊断的敏感度为73.77%,特异度为67.86%,准确度为70.94%,阳性预测值为71.43%,阴性预测值为70.37%。多点注射亚甲蓝联合超声对前哨淋巴结诊断的敏感度、特异度、准确度、阴性预测值均高于单点注射亚甲蓝(P<0.05)。结论:多点注射亚甲蓝联合超声在乳腺癌前哨淋巴结活检术中应用,可提高诊断的效能,指导患者的诊治,为患者预后的改善奠定基础。
Objective:To explore the application value of multi-point injection of Methylthioninium Chloride combined with ultrasound in sentinel lymph node biopsy of breast cancer.Method:A total of 100 patients with breast cancer who underwent sentinel lymph node biopsy in Longyan First Hospital Affiliated to Fujian Medical University from January 2020 to January 2021 were selected.They were grouped according to whether or not ultrasound was used during sentinel lymph node biopsy of breast cancer.Among them,50cases of intraoperative multi-point injection of Methylthioninium Chloride combined with ultrasound were the experimental group,and 50 cases of single point injection of Methylthioninium Chloride were the control group.The detection condition of sentinel lymph nodes in the two groups was observed.Taking the pathological results as the gold standard,the diagnostic results of the two methods were analyzed,and the diagnostic efficacy of the two methods for sentinel lymph nodes was compared,including sensitivity,specificity,accuracy,positive predictive value and negative predictive value.Result:There was no significant difference in the detection rate of sentinel lymph nodes between the two groups(P>0.05).The sensitivity of multi-point injection of Methylthioninium Chloride combined with ultrasound in the diagnosis of sentinel lymph nodes was 93.62%,the specificity was 91.76%,the accuracy was 92.42%,the positive predictive value was 86.27%,and the negative predictive value was 96.30%.The sensitivity of single point injection of Methylthioninium Chloride in the diagnosis of breast sentinel lymph nodes was 73.77%,the specificity was 67.86%,the accuracy was 70.94%,the positive predictive value was 71.43%,and the negative predictive value was 70.37%.The sensitivity,specificity,accuracy and negative predictive value of sentinel lymph node diagnosis of multi-point injection of Methylthioninium Chloride combined with ultrasound were higher than those of single point injection of Methylthioninium Chloride(P<0.05).Conclusion:The ap
作者
李蒙玲
杨先荣
苏密龙
涂兴峰
LI Mengling;YANG Xianrong;SU Milong;TU Xingfeng(Longyan First Hospital Affiliated to Fujian Medical University,Longyan 364000,China;不详)
出处
《中外医学研究》
2022年第16期77-80,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
2017年福建省科技计划项目(2017J01228)。
关键词
多点注射
亚甲蓝
超声造影
乳腺癌
前哨淋巴结
活检术
Multi-point injection
Methylthioninium Chloride
Contrast-enhanced ultrasound
Mammary cancer
Sentinel lymph nodes
Biopsy
