摘要
慢性肾脏病(CKD)已成为全球性的公共卫生问题,CKD患者的最终结局往往会发展为终末期肾病(ESRD)。肾间质纤维化(RIF)是不同病因的CKD进展为ESRD的共同途径。因发病机制复杂,目前RIF尚无有效的治疗方法,近期研究表明外泌体在多种肾脏疾病的发生发展中发挥着重要作用。该文对外泌体在RIF发病机制中作用的最新研究进展进行综述,探讨外泌体在RIF诊断与治疗中的前景及挑战。
Chronic kidney disease(CKD)has become a global public health event.CKD may eventually progress into endstage renal disease(ESRD).Renal interstitial fibrosis(RIF)is the common pathway for the progression from CKD into ESRD.Due to the complex pathogenesis,there is currently no effective treatment for RIF.Recent studies have shown that exosomes play an important role in the occurrence and development of a variety of kidney diseases.In this article,the latest research progress on the role of exosomes in the pathogenesis of RIF was reviewed,and the application prospect of exosomes in the diagnosis and treatment of RIF was investigated.
作者
宋晓红
郭兆安
Song Xiaohong;Guo Zhaoan(The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Ji’nan 250014,China;不详)
出处
《新医学》
CAS
2022年第7期469-473,共5页
Journal of New Medicine
关键词
肾间质纤维化
外泌体
发病机制
人工外泌体
Renal interstitial fibrosis
Exosome
Pathogenesis
Artificial exosome
