摘要
粒子设计基于质量源于设计的理念,结合了配方科学、界面学、传热与传质、固态物理学、粉体学、纳米技术等,广泛应用于开发功能性质优良的粒子。基于粒子设计理论的中药粉体改性技术,在不影响中药药效物质基础的前提下,从物理结构层面改善中药粉体的流动性、压缩性、崩解和溶出行为、引湿性、润湿性等功能性质,极大推动了中药固体制剂的发展。本综述通过对近十年的相关研究进行总结,分别从粒子设计原理、粉体改性技术、粉体改性所用设备、在中药粉体中的应用及改性机制进行概述,以期对粒子设计的发展提供一定的思路与理论基础。
Particle design, based on the concept of "quality by design", combines the elements of microbiology,formulation science, heat and mass transfer, solid state physics, powder science, and nanotechnology. It is widely used to develop particles with excellent functional properties. Without affecting the active ingredients, the modification technology of traditional Chinese medicine(TCM) powder based on particle design theory, could improve the flowability, tabletability, disintegration and dissolution behavior, hygroscopicity, wettability, and other functional properties at the physical structure level. This greatly promotes the development of solid preparations of TCM. The present review aims to summarize and discuss the research progress of powder modification of TCM from the perspective of the theory of particle design, powder modification technology, equipment used for powder modification, application in TCM and modification mechanism mainly based on researches published in recent ten years. This review could provide ideas and theory basis for the development of particle design.
作者
朱卫丰
陈富财
刘文君
明良山
管咏梅
陈丽华
李哲
ZHU Wei-feng;CHEN Fu-cai;LIU Wen-jun;MING Liang-shan;GUAN Yong-mei;CHEN Li-hua;LI Zhe(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Institute for Advanced Study,Research Center for Differentiation and Development of TCM Basic Theory,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangzhong Pharmaceutical Co.Ltd.,Nanchang 330049,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第6期1781-1791,共11页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(82003953)
中华中医药学会2020~2022年度青年人才托举工程项目(2020-QNRC2-07)
中国博士后科学基金面上项目(2019M662278)
江西省自然科学基金资助项目(20202BAB216039)
江西省教育厅科学技术研究项目(GJJ190688)。
关键词
粒子设计
中药粉体改性
粒子设计原理
粉体改性技术
粉体改性设备
particle design
powder modification based on traditional Chinese medicine
theory of particle design
technology for powder modification
equipment for powder modification
