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妊娠合并精神分裂症患者血清中IL-1β、IL-6的表达水平及其与妊娠结局的相关性 被引量:1

Correlation between the Expression Levels of Serum IL-1βand IL-6 and Pregnancy Outcome in Patients with Pregnancy Complicated with Schizophrenia
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摘要 【目的】探讨妊娠合并精神分裂症患者血清白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)的表达水平及其与妊娠结局的相关性。【方法】选取2020年1月至12月在延安大学附属医院产科分娩的妊娠合并精神分裂症患者37例(观察组)和正常孕妇28例(对照组)。采用酶联免疫吸附法(ELISA)检测所有受试者血清IL-1β和IL-6表达水平;采用Pearson分析IL-1β和IL-6表达水平的相关性及IL-1β、IL-6表达水平与不良妊娠结局的相关性;采用受试者工作特征曲线(ROC曲线)分析IL-1β、IL-6表达水平对不良妊娠结局的预测价值。【结果】与对照组比较,观察组血清IL-1β和IL-6表达水平升高(P<0.05);血清IL-1β与IL-6表达呈正相关(r=0.54,P<0.05);观察组早产、胎膜早破、胎盘早剥、产后出血发生率显著高于对照组(P<0.05);胎儿低体重、胎儿畸形、胎儿窘迫、围生儿死亡和重度窒息发生率显著高于对照组(P<0.05);血清IL-1β、IL-6表达与不良妊娠结局呈正相关(P<0.05);ROC曲线分析显示:血清IL-1β、IL-6预测不良妊娠结局的曲线下面积(AUC)分别为0.883、0.864,二者联合预测不良妊娠结局的AUC为0.891。【结论】妊娠合并精神分裂症可增加妊娠不良结局发生率,血清IL-1β和IL-6在妊娠合并精神分裂症患者血清中呈高表达,其与妊娠合并精神分裂症患者不良妊娠结局密切相关,可为妊娠合并精神分裂症病情监控提供依据。 【Objective】To investigate the correlation between the expression levels of serum interleukin-1β(IL-1β)and interleukin-6(IL-6)and pregnancy outcome in patients with pregnancy complicated with schizophrenia.【Methods】A total of 37 pregnant women with schizophrenia(observation group)and 28 normal pregnant women(control group)who delivered in the obstetrics department of the Affiliated Hospital of Yan'an University from January 2020 to December 2020 were selected.The expression levels of serum IL-1βand IL-6 in all subjects were detected by enzyme-linked immunosorbent assay(ELISA);Pearson was used to analyze the correlation between the expression levels of IL-1βand IL-6 and the correlation between the expression levels of IL-1βand IL-6 and adverse pregnancy outcomes;ROC curve was used to analyze the predictive value of IL-1βand IL-6 expression levels on adverse pregnancy outcomes.【Results】Compared with the control group,the expression levels of serum IL-1βand IL-6 in the observation group increased(P<0.05);There was a positive correlation between the expression of serum IL-β1 and IL-6(r=0.54,P<0.05);The incidence of premature delivery,premature rupture of membranes,placental abruption and postpartum hemorrhage in the observation group was significantly higher than that in the control group(P<0.05);The incidence of low fetal weight,fetal malformation,fetal distress,perinatal death and severe asphyxia in the control group were significantly higher than those in the control group(P<0.05);The expression of serum IL-1βand IL-6 was positively correlated with adverse pregnancy outcome(P<0.05);ROC curve analysis showed that the area under the curve(AUC)of serum IL-1βand IL-6 in predicting adverse pregnancy outcomes were 0.883 and 0.864 respectively,and the AUC of combined prediction of adverse pregnancy outcomes was 0.891.【Conclusion】Pregnancy complicated with schizophrenia can increase the incidence of adverse pregnancy outcomes.Serum IL-1βand IL-6 are highly expressed in the serum of patients with
作者 张瑞 白瑜 ZHANG Rui;BAI Yu(The Third Ward of Obstetrics,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi 716000)
出处 《医学临床研究》 CAS 2022年第5期740-742,746,共4页 Journal of Clinical Research
关键词 妊娠 精神分裂症 白细胞介素1β/血液 白细胞介素6/血液 妊娠结局 Pregnancy Schizophrenia Interleukin-1 beta/BL Interleukin-6/BL Pregnancy Outcome
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