摘要
目的探讨影响成人高级别脑胶质瘤术后复发的相关因素,为提高脑胶质瘤的诊疗水平、降低复发率提供临床依据。方法回顾性分析2018年1月~2020年12月在杭州市肿瘤医院进行术后辅助放化疗的44例高级别脑胶质瘤患者的临床资料。记录患者的基本信息的分子病理、影像学检查及治疗经过等可能影响预后的因素。采用Kaplan–Meier法对相关因素进行生存分析,采用Log–Rank检验、Cox回归模型分别进行单因素和多因素分析。结果患者中位无进展生存(progress free survive,PFS)时间为8.8个月。单因素分析结果显示,放疗前卡氏功能状态(Karnofsky performance status,KPS)评分、肿瘤切除程度、异柠檬酸脱氢酶(isocitrate dehydrogenase,IDH)表达均是影响成人高级别脑胶质瘤患者PFS时间的重要因素(均P<0.05)。多因素分析结果显示,放疗前KPS评分<70分、肿瘤切除不全、IDH野生型均是成人高级别脑胶质瘤术后复发的独立危险因素(均P<0.05)。结论高级别脑胶质瘤患者预后差,复发率高。放疗前KPS评分<70分、肿瘤切除不全、IDH野生型的高级别脑胶质瘤患者术后复发率较高。
Objective To explore the related factors affecting postoperative recurrence of high–level glioma,and to provide clinical evidence for improving the clinical treatment level and reducing the recurrence rate.Methods The clinical data of 44 patients with high–grade glioma who received postoperative adjuvant chemoradiotherapy in Hangzhou Cancer Hospital from January 2018 to December 2020 were retrospectively analyzed.Factors that may influence prognosis were recorded,such as patient information,molecular pathology,imaging,and treatment.Kaplan–Meier method was used for survival analysis,and Log–Rank test and Cox regression were used for univariate and multivariate analysis of prognostic factors.Results The median progress free survive(PFS)was 8.8 months.The univariate analysis showed that Karnofsky performance status(KPS)score before radiotherapy,tumor resection degree and isocitrate dehydrogenase(IDH)expression were important factor affecting of PFS in adult high–grade glioma patients(all P<0.05).The multivariate analysis showed that KPS score<70,incomplete tumor resection,IDH wild type were independent risk factors for adult high–grade glioma recurrence(all P<0.05).Conclusion High–grade glioma patients have poor prognosis and high recurrence rate.High–grade gliomas with KPS score<70 before radiotherapy,incomplete tumor resection and IDH wild type had higher postoperative recurrence.
作者
张晴
戴慧
ZHANG Qing;DAI Hui(Department of Radiotherapy,Hangzhou Cancer Hospital,Hangzhou 310002,China)
出处
《中国现代医生》
2022年第19期30-34,共5页
China Modern Doctor
关键词
高级别脑胶质瘤
术后放疗
复发
危险因素
High–grade glioma
Postoperative radiotherapy
Recurrence
Risk factor
