摘要
目的研究布地奈德联合阿奇霉素序贯治疗小儿迁延性肺炎支原体肺炎的效果及对免疫球蛋白水平的影响。方法根据随机数字表法将70例迁延性肺炎支原体肺炎患儿分为对照组和观察组,每组35例。在常规对症治疗的基础上,对照组采取阿奇霉素序贯治疗,观察组采取布地奈德联合阿奇霉素序贯治疗。比较两组治疗效果。结果治疗后,观察组诱导痰液中肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、可溶性髓系细胞触发受体1(sTREM-1)水平,血清C反应蛋白(CRP)、TNF-α、白细胞介素6(IL-6)水平低于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平高于对照组(P<0.05)。治疗后,观察组的免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平高于对照组(P<0.05)。治疗后,观察组的呼气流量峰值(PEF)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)高于对照组,呼吸频率(RR)低于对照组(P<0.05)。观察组的退热时间、止咳时间、喘息消失时间、肺啰音消失时间、X线胸片复常时间均短于对照组,治疗总有效率高于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论布地奈德联合阿奇霉素序贯治疗小儿迁延性肺炎支原体肺炎的效果良好,可减轻炎症反应和氧化应激反应,改善患儿的免疫功能、肺功能,缓解临床症状/体征,安全性良好。
Objective To study the effect of budesonide combined with azithromycin sequential therapy on children with persistent Mycoplasma pneumoniae pneumonia and its influences on immunoglobulin levels.Methods Seventy children with persistent Mycoplasma pneumoniae pneumonia were divided into control group and observation group by random number table method,with 35 cases in each group.On the basis of routine symptomatic treatment,the control group was given azithromycin sequential therapy,and the observation group was given budesonide combined with azithromycin sequential therapy.The therapeutic effects of the two groups were compared.Results After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)and soluble triggering receptor expression on myeloid cell-1(sTREM-1)in induced sputum,and the levels of serum C-reactive protein(CRP),TNF-αand interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,while the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were higher than those in the control group(P<0.05).After treatment,the levels of immunoglobulin A(IGA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the observation group were higher than those in the control group(P<0.05).After treatment,the peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),forced vital capacity(FVC)in the observation group were higher than those in the control group,while the respiratory rate(RR)was lower than that in the control group(P<0.05).The fever relieving time,cough relieving time,wheezing disappearance time,lung rale disappearance time and chest X-ray normalization time in the observation group were shorter than those in the control group,while the total effective rate of treatment was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the tw
作者
郝应娥
郝丽梅
HAO Ying'e;HAO Limei(Traditional Chinese Medicine Hospital of Yulin,Yulin 719000,China)
出处
《临床医学研究与实践》
2022年第20期74-77,共4页
Clinical Research and Practice
关键词
迁延性肺炎支原体肺炎
布地奈德
阿奇霉素
序贯治疗
免疫球蛋白
persistent Mycoplasma pneumoniae pneumonia
budesonide
azithromycin
sequential therapy
immunoglobulin
