摘要
目的 评估慢性盘状红斑狼疮患者应用他克莫司与曲安奈德治疗的效果。方法 选取2020年1月~2021年1月中国人民解放军联勤保障部队第九七〇医院收治的慢性盘状红斑狼疮患者66例,通过随机数字表法分为对照组与观察组,每组各33例。对照组给予曲安奈德治疗,观察组给予他克莫司治疗,比较两组患者的治疗总有效率、疾病复发率、不良反应发生率、口腔糜烂面积、视觉模拟疼痛评分(VAS评分)、C-反应蛋白(CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)。结果 (1)观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);(2)观察组的复发率低于对照组,差异有统计学意义(P<0.05)。(3)观察组的不良反应(短暂性刺痛感、轻微灼痛感、瘙痒、皮肤干燥)发生率低于对照组,差异有统计学意义(P<0.05)。(4)观察组的口腔糜烂面积小于对照组,观察组的VAS评分低于对照组,差异有统计学意义(P<0.05)。(5)观察组的CRP、IL-1β、TNF-α均低于对照组,差异有统计学意义(P<0.05)。结论 慢性盘状红斑狼疮患者应用他克莫司与曲安奈德治疗均可以取得一定的效果,但是他克莫司的疗效更佳,不良反应更低,值得在临床中推广使用。
Objective To evaluate the effect of tacrolimus and triamcinolone acetonide in the treatment of chronic discoid erythema. Methods A total of 66 patients with chronic discoid erythema who visited the 970th Hospital of the People′s Liberation Army Joint Logistic Support Force from January 2020 to January 2021 were selected. They were divided into the control groups and the observation group using random number table method, with 33 patients in each group. The control group were treated with tacrolimus and the observation group were given triamcinolone acetonide.The total effective rate, recurrence rate, incidence of adverse events, oral erosion area, visual analog pain score(VAS score), C-reactive protein(CRP), interleukin-1 β(IL-1 β), and TNF-α(TNF-α) were compared between the two groups. Results(1)The total effective rate in the observation group was higher than that in the control group, with statistically significant difference(P<0.05).(2)The recurrence rate in the observation group was lower than that in the control group, with statistically significant difference(P<0.05).(3)The incidence of adverse events(transient tingling sensation,slight burning sensation, itching, and dry skin) in the observation group was lower than that in the control group, with statistically significant difference(P<0.05).(4)The oral erosion area in the observation group was smaller than that in the control group, and the VAS score in the observation group was lower than that in the control group, with statistically significant differences(P<0.05).(5)The CRP, IL-1β and TNF-α in the observation group were lower than those in the control group, with statistically significant differences(P <0.05). Conclusion Tacrolimus and triamcinolone acetonide can both achieve certain results in the treatment of chronic discoid erythema. Tacrolimus has a better efficacy with fewer adverse events, and should be popularized in clinical practice.
作者
杨道秋
王山花
YANG Daoqiu;WANG Shanhua(Department of Dermatology,the 970th Hospital of the People′s Liberation Army Joint Logistic Support Force,Yantai 264002,China;Department of scientific research,Comprehensive Health Service Center,Yantai 264000,China)
出处
《中国现代医生》
2022年第16期106-109,共4页
China Modern Doctor
