摘要
目的:探讨糜烂型口腔扁平苔藓(OLP)患者联用他克莫司与口服蒲地蓝治疗的临床效果及对患者免疫功能的影响。方法:196例糜烂型OLP患者作为本研究的观察对象,均为我院2019年1月—2020年7月收治。遵循随机数字表法对所有观察对象进行分组,对照组与联合组各有98例患者。对照组外用他克莫司软膏治疗,联合组外用他克莫司并口服蒲地蓝治疗。对两组的治疗效果以及治疗前后的视觉模拟评分(VAS)进行评价,检测比较两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标治疗前后水平的变化;对所有患者治疗后随访6个月,评价复发率。结果:在临床治疗总有效率方面,联合组较对照组提高(93.88%VS 82.65%)(P<0.05)。在VAS评分及糜烂面积方面,两组治疗后均低于治疗前(P<0.05)。治疗后联合组VAS评分及糜烂面积低于对照组(P<0.05)。在CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)等免疫功能指标水平方面,治疗后两组均升高(P<0.05)。治疗后联合组免疫功能指标水平高于对照组(P<0.05)。对所有患者治疗后治疗6个月,联合组复发率较对照组显著降低(8.16%VS 19.39%,P=0.023)。结论:糜烂型OLP患者在外用他克莫司软膏治疗的基础上口服蒲地蓝口服液可以减轻患者疼痛程度,减小糜烂面积,取得的治疗效果满意,复发率较低,考虑可能与改善患者机体免疫功能有关。
Objective:To investigate the clinical effect of tacrolimus combined with oral Pudilan in patients with erosive oral lichen planus(OLP)and its effect on immune function.Method:196 patients with erosive OLP were treated in our hospital from January 2019 to July 2020.All the subjects were grouped according to the random number table method.There were 98 patients in the control group and 98 patients in the combined group.The control group was treated with tacrolimus ointment,and the combined group was treated with tacrolimus and oral Pudilan.The treatment effect and visual analogue scale(VAS)before and after treatment were evaluated,and the changes of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)indexes before and after treatment were detected and compared between the two groups;All patients were followed up for 6 months to evaluate the recurrence rate.Result:The total effective rate of the combined group was higher than that of the control group(93.88%VS 82.65%)(P<0.05).The VAS score and erosion area of the two groups after treatment were lower than those before treatment(P<0.05).After treatment,the VAS score and erosion area in the combined group were lower than those in the control group(P<0.05).The levels of immune function indexes such as CD3^(+),CD4^(+),CD4^(+)/CD8^(+)increased in both groups after treatment(P<0.05).After treatment,the level of immune function indexes in the combined group was higher than that in the control group(P<0.05).After 6 months of treatment,the recurrence rate in the combined group was significantly lower than that in the control group(8.16%VS 19.39%,P=0.023).Conclusion:On the basis of oral administration of borneol ointment,the patients with OLP can be treated with Borneol ointment,which can reduce the recurrence rate of patients with OLP.
作者
孙骞
Sun Qian(Department of Stomatology,Fukuang General Hospital of Liaoning Health Industry Group,Fuxin Liaoning 123000)
出处
《黑龙江医药》
CAS
2022年第3期630-633,共4页
Heilongjiang Medicine journal
