摘要
目的研究VELscope自体荧光检查在糜烂型口腔扁平苔藓(oral lichen planus,OLP)诊断及恶变筛查中的应用效果。方法收集2019年9月至2021年9月就诊于徐州市中心医院口腔科经临床检查初步诊断符合糜烂型OLP患者138例,随机分为研究组和对照组,每组各69例。研究组通过VELscope自体荧光检查确定组织活检部位,对照组根据临床医生经验选取组织活检部位。根据2003年修订的WHO改良OLP诊断标准对两组患者进行诊断,并计算糜烂型OLP检出率。对糜烂型OLP阳性患者做进一步分析,计算糜烂型OLP恶性筛出率。结果研究组患者糜烂型OLP检出率为91.30%,明显高于对照组(76.81%),差异有统计学意义(χ^(2)=5.408,P=0.020)。研究组患者糜烂型OLP恶性筛出率(14.28%)也明显高于对照组(1.92%),差异有统计学意义(χ^(2)=4.154,P=0.042)。结论VELscope自体荧光检查对于糜烂型OLP患者病理组织活检部位的选择具有指导意义,其还可应用于糜烂型OLP恶变的早期筛查。
Objective To study the application of VELscope autofluorescence examination in the diagnosis and malignancy screening of erosive oral lichen planus(OLP).Methods A total of 138 patients with erosive OLP initially diagnosed in the Department of Stomatology of Xuzhou Central Hospital from September 2019 to September 2021 were randomly divided into study group and control group,with 69 cases in each group.In the study group,the biopsy site was determined by VELscope autofluorescence examination,and in the control group,the biopsy site was selected according to the experience of clinicians.The two groups were diagnosed according to the WHO modified OLP diagnostic criteria revised in 2003,and the detection rate of erosive OLP was calculated.Further analysis was performed in erosive OLP positive patients to calculate the malignancy screening rate of erosive OLP.Results The detection rate of erosive OLP in the study group was 91.30%,which was significantly higher than that in the control group(76.81%)(χ^(2)=5.408,P=0.020).The malignancy screening rate of erosive OLP in the study group(14.28%)was significantly higher than that in the control group(1.92%),and the difference was statistically significant(χ^(2)=4.154,P=0.042).Conclusion VELscope autofluorescence examination is of guiding significance in the selection of biopsy sites for patients with erosiveOLP,and may also have important clinical significance in the screening of patients with erosive OLP malignancies.
作者
王映
李志萍
王浩然
孟箭
彭森
WANG Ying;LI Zhi-ping;WANG Hao-ran;MENG Jian;PENG Sen(不详;School of Stomatology,Bengbu Medical College,Bengbu 233030,China)
出处
《中国实用口腔科杂志》
CAS
2022年第2期212-215,共4页
Chinese Journal of Practical Stomatology
基金
国家口腔疾病临床医学研究中心项目(NCRCO—202101)
徐州市重点研发计划(KC20088)
蚌埠医学院研究生科研创新计划(Byycx20063)。
