摘要
肠易激综合征(irritable bowel syndrome,IBS)是临床常见的一种功能性胃肠病,其发病机制比较复杂,严重影响患者的生活质量.目前认为IBS发病机制主要涉及内脏感觉异常、肠道动力紊乱、免疫失调及肠道屏障损伤等.因IBS发病存在女性偏倚,强烈提示雌激素等性激素参与IBS的发生发展.此外,肠道菌群失调与IBS密切相关.雌激素和肠道菌群如何相互影响参与IBS尚未被完全阐释.本文对当前相关研究进展进行述评.在梳理新发现和研究不足的基础上,探讨今后的研究方向和需要注意的问题.
Irritable bowel syndrome(IBS)is a common functional gastrointestinal disorder with a complex pathogenesis that has a serious impact on the quality of life of patients.Abnormal visceral sensation,disordered gut motility,dysregulated immunity,and damaged intestinal barrier are thought to be involved in the pathogenesis of IBS.Female predisposition to IBS strongly suggests that sex hormones such as estrogen are involved in the development of IBS.In addition,dysbiosis of the intestinal flora is closely related to IBS.The interaction between estrogen and gut microbiota in IBS has not been fully elucidated.This review summarizes and evaluates the progress of related studies.Based on the new findings and shortcomings of current studies,we discuss the directions and issues that need to be resolved in future research.
作者
蒋风茹
杭露
周盐
冯雅
袁建业
Feng-Ru Jiang;Lu Hang;Yan Zhou;Ya Feng;Jian-Ye Yuan(Institute of Digestive Diseases,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《世界华人消化杂志》
CAS
2022年第12期511-520,共10页
World Chinese Journal of Digestology
关键词
雌激素
肠道菌群
肠易激综合征
Estrogen
Gut microbiota
Irritable bowel syndrome
