摘要
通过水相滴定法及伪三元相图法初步筛选青刺果油纳米乳配方,确定以PEG-20氢化蓖麻油(CO-20)为乳化剂,聚乙二醇-200(PEG-200)为助乳化剂,再以平均粒径为评价指标,采用Box-Behnken设计-响应面法优化配方。结果表明,最佳配方下所得青刺果油纳米乳的平均粒径为31.58 nm、多分散系数(polydispersity,PDI)为0.18、Zeta电位为-6.38 mV,在透射电子显微镜下其形态呈均一球型,具有离心稳定性、稀释稳定性及温度稳定性,为青刺果油纳米乳的制备提供了参考。
Aqueous titration method and pseudo-ternary phase diagram method were used to preliminatively determine the formulation of Prinsepia utilis Royle oil nanoemulsion.PEG-20 hydrogenated castor oil(CO-20)was confirmed as emulsifier,polyethylene glycol 200(PEG-200)was confirmed as co-emulsifier,and the average particle size was taken as evaluation index.Box-behnken design-response surface method was used to optimize the formulation.The results showed that that the average particle size,polydispersity(PDI)and Zeta potential were 31.58 nm,0.18 and-6.38 mV under the optimal formulation of Prinsepia utilis Royle oil nanoemulsion.It had a uniform spherical shape under the transmission electron microscope with centrifugal stability,dilution stability,and temperature stability,which provided a reference for the preparation of Prinsepia utilis Royle oil nanoemulsion.
作者
白月明
张霞
谢雪勤
孟达
车彦云
赵毅
BAI Yue-ming;ZHANG Xia;XIE Xue-qin;MENG Da;CHE Yan-yun;ZHAO Yi(College of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650000,Yunnan,China;Engineering Research Center for Medicine and Food Homologous Beverage of Yunnan Province,Kunming 650000,Yunnan,China)
出处
《粮食与油脂》
北大核心
2022年第6期62-66,84,共6页
Cereals & Oils
关键词
青刺果油
纳米乳
伪三元相图
配方优化
响应面法
Prinsepia utilis Royle oil
nanoemulsion
pseudo-ternary phase diagram
formulation optimization
response surface method
