摘要
目的探讨清燥救肺汤加减联合百令胶囊治疗慢性咳嗽的临床疗效,以及对患者炎性因子水平及免疫功能的影响。方法选取医院2019年1月至2021年1月收治的慢性咳嗽患者120例,按随机数字表法分为观察组和对照组,各60例。两组患者均予百令胶囊和磷酸可待因片,观察组加用清燥救肺汤加减,均连续治疗8周。结果观察组总有效率为93.33%,显著高于对照组的78.33%(P<0.05)。治疗后,观察组患者中医证候(咳嗽、咽痛、呕吐、乏力)积分均显著低于对照组(P<0.05);观察患者炎性因子中性粒细胞计数、转化生长因子β1、白细胞介素1β水平均显著低于对照组(P<0.05);观察组患者T淋巴细胞亚群CD3+,CD4+,CD4+/CD8+水平均显著高于对照组,CD8+水平显著低于对照组(P<0.05)。观察组和对照组治疗期间药品不良反应发生率相当(13.33%比8.33%,P>0.05)。结论清燥救肺汤加减联合百令胶囊和磷酸可待因片治疗慢性咳嗽临床疗效较好,可有效改善患者的中医证候,降低炎性因子水平,提升免疫功能,且治疗安全性良好。
Objective To investigate the clinical efficacy of modified Qingzaojiufei Decoction combined with Bailing Capsules in the treatment of chronic cough,and its effect on the level of inflammatory factors and immune function of patients.Methods A total of 120 patients with chronic cough admitted to the hospital from January 2019 to January 2021 were selected and divided into the observation group and the control group according to the random number table method,with 60 cases in each group.The patients in both groups were given Bailing Capsules and Codeine Phosphate Tablets,on this basis,the patients in the observation group were given modified Qingzaojiufei Decoction.Both groups were treated for continuous eight weeks.Results The total effective rate in the observation group was 93.33%,which was significantly higher than 78.33%in the control group(P<0.05).After treatment,the scores of traditional Chinese medicine(TCM)syndromes such as cough,sore throat,vomiting and fatigue in the observation group were significantly lower than those in the control group(P<0.05).The levels of inflammatory factors such as neutrophil count(NEUT),transforming growth factor-β1(TGF-β1)and interleukin-1β(IL-1β)in the observation group were significantly lower than those in the control group(P<0.05).The levels of T lymphocyte subsets such as CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group,while the level of CD8+in the observation group was significantly lower than that in the control group(P<0.05).During the treatment,the incidence of adverse drug reactions in the observation group was similar to that in the control group(13.33%vs.8.33%,P>0.05).Conclusion Modified Qingzaojiufei Decoction combined with Bailing Capsules and Codeine Phosphate Tablets is effective and safe in the treatment of chronic cough,which can improve the TCM syndromes,decrease the level of inflammatory factors and improve the immune function of patients.
作者
冯超
王秀兰
FENG Chao;WANG Xiulan(Chinese Medicine Hospital of Hainan Province,Haikou,Hainan,China 570203)
出处
《中国药业》
CAS
2022年第13期103-106,共4页
China Pharmaceuticals
基金
海南省医药卫生科研项目[1801360101A2004]。
关键词
清燥救肺汤加减
百令胶囊
慢性咳嗽
临床疗效
炎性因子
免疫功能
modified Qingzaojiufei Decoction
Bailing Capsules
chronic cough
clinical efficacy
inflammatory factor
immune function
