摘要
目的探讨血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)的相关性。方法选取参加2019年度开滦集团职工健康查体,年龄≥40岁且符合入组标准、资料完整者5136名作为研究对象。采用横断面调查研究方法,进行统一问卷调查(包括行血液生化及颈动脉彩超检查)。依据2003美国心脏协会(American Heart Association,AHA)公布的hs-CRP诊断标准,将研究对象分为3组:0.05 mg/L0.84 mm组,采用χ^(2)趋势检验及逐步后退法多因素Logistic回归模型分析,结果显示hs-CRP浓度较高时,CIMT随着hs-CRP的增高而增厚[OR值(95%CI)为1.24(1.01~1.52),P<0.05]。结论hs-CRP与CIMT具有相关性,高hs-CRP者CIMT增厚,动脉粥样硬化性疾病的风险增加。
Objective To investigate the correlation between serum high sensitivity C-reactive protein and carotid intima-media thickness.Methods A total of 5136 health examination subjects,aged≥40 years old,who met the inclusion criteria and had complete data,were selected as the research objects.A unified questionnaire survey,blood biochemistry and carotid artery color doppler ultrasound examination were performed.According to the diagnostic criteria of hs-CRP published by American Heart Association(AHA),the subjects were divided into three groups:0.05 mg/L<hs-CRP<1.00 mg/L,1.00 mg/L≤hs-CRP<3.00 mg/L,and hs-CRP≥3.00-10.00 mg/L.Stepwise linear regression,χ^(2) trend test and stepwise regression analysis were used to explore the correlation between hs-CRP and CIMT.Results(1)Five thousand one hundred and thirty-six patients were enrolled,including 3048 males and 2088 females,aged(54.87±11.65)years.(2)Taking CIMT as the dependent variable and hs-CRP(converted by Lg)as the independent variable,the stepwise linear regression analysis using the entry method showed that there was a linear correlation between hs-CRP and CIMT,and the standard regression coefficient was 1.107(P<0.01).(3)According to this study,CIMT was divided into two groups,CIMT≤0.84 mm group and CIMT>0.84 mm group.The results showed that when the concentration of hs-CRP was high,CIMT increased with the increase of hs-CRP(OR(95%CI)1.24(1.01~1.52),P<0.05).Conclusion There was a positive correlation between hs-CRP and CIMT.Patients with higher levels of hs-CRP are more likely to develop CIMT thickening and increase the risk of arteriosclerotic disease.
作者
张莹
杜鑫
李劼
马琳
张树华
吴寿岭
季春鹏
施继红
郭蕊
Zhang Ying;Du Xin;Li Jie;Ma Lin;Zhang Shuhua;Wu Shouling;Ji Chunpeng;Shi Jihong;Guo Rui(Department of Ultrasound,North China University of Science and Technology Affiliated Hospital,Tangshan 063000,China;Department of Cardiology,Kailuan Hospital,Tangshan,Hebei,063000;Science and education,North China University of Science and Technology Affiliated Hospital Tangshan)
出处
《中国综合临床》
2021年第1期26-30,共5页
Clinical Medicine of China
基金
河北省医学科学研究重点课题计划项目(20191131)。
关键词
超敏C反应蛋白
颈动脉内膜中层厚度
相关性分析
High sensitivity C-reactive protein
Carotid intima-media thickness
Correlation analysis
