摘要
目的探讨福建地区无症状性颈动脉狭窄患者危险因素及对血清生物标记物表达的影响。方法采用横断面研究,以2013年1月~2014年6月福建地区心脑血管病高危人群269例为研究对象,根据颈动脉彩色多普勒超声检查结果分为颈动脉狭窄组25例（颈动脉狭窄≥50%）,对照组244例（颈动脉狭窄0~49%）,采用ELISA测定研究对象血清基质金属蛋白酶（MMP）-1,MMP-7、白细胞介素8和高敏C反应蛋白水平,分析各组间血管危险因素以及炎性生物标记物表达的差异。结果颈动脉狭窄组年龄、脑卒中家族史和高血压比例明显高于对照组（P〈0.05,P〈0.01）。颈动脉狭窄组血清MMP-1和MMP-7水平明显高于对照组[（160.63±34.88）μg/Lvs（105.39±14.06）μg/L,P=0.000;（16.38±0.88）μg/L vs（15.73±0.92）μg/L,P=0.003）]。结论合并年龄增长、高血压和脑卒中家族史3个危险因素的个体应注重颈动脉狭窄的早期筛查和防治。
Objective To tudy the risk factors for asymptomatic carotid stenosis in Fujian Province and their effect on expression of serum biomarkers.Methods Two hundred and sixty-nine patients at high risk of cerebrovascular disease from Fujian Province admitted to our hospital from January 2013 to June 2014 were divided into carotid atherosclerotic stenosis group with its carotid atherosclerotic stenosis≥50%（n=25）and control group with its carotid atherosclerotic stenosis〈50%（n=244）.Serum levels of MMP-1,MMP-7,IL-8,and hs-CRP were measured by ELISA.Risk factors for asymptomatic carotid stenosis and expression of inflammatory biomarkers were analyzed.Results The age was significantly older,the family history of ischemic stroke and the incidence of hypertension were significantly higher in carotid atherosclerotic stenosis group than in control group（P〈0.05,P〈0.01）.The serum levels of MMP-1and MMP-7were significantly higher in carotid atherosclerotic stenosis group than in control group（P〈0.01）.Conclusion Importance should be attached to the early diagnosis and treatment of carotid artery stenosis in elderly patients with hypertension and family history of ischemic stroke.
出处
《中华老年心脑血管病杂志》
CAS
2016年第11期1137-1139,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
福建省科技厅重点项目(2013Y0042)
