摘要
糖尿病肾脏病是常见的糖尿病微血管并发症之一。研究发现早期糖尿病肾脏病患者肾内就已发现有异位脂质沉积, 其可引起肾内细胞发生脂毒性损伤。异位脂质沉积主要与脂肪酸摄取、氧化利用失衡及脂代谢紊乱有关。本文从异位脂质沉积导致肾脏结构改变、肾内异位脂质沉积形成以及其形成后导致肾脏受损诱发糖尿病肾脏病最新机制进行了详细阐述, 同时就基于上述机制进行的治疗进行了总结, 为糖尿病肾脏病治疗提供了新的方向。
Diabetic kidney disease is one of the common diabetic microvascular complications.In patients with early diabetic kidney disease,ectopic lipid deposition has been found in the kidney,which can cause lipotoxic damage to renal cells.It has been found that ectopic lipid deposition is mainly related to fatty acid uptake,oxidation imbalance and lipid metabolism disorder.In this paper,the latest mechanism of ectopic lipid deposition leading to changes in renal structure and function,the formation of ectopic lipid deposition in the kidney,and its formation leading to kidney damage and diabetic kidney disease are described in detail,and the treatment based on the above mechanism is also discussed.In conclusion,it provides a new direction for the treatment of diabetic kidney disease.
作者
谷巍
宋光耀
李晓龙
Gu Wei;Song Guangyao;Li Xiaolong(Department of Endocrinology,Hengshui People's Hospital,Hengshui 053000;Department of Endocrinology,Hebei General Hospital,Shijiazhuang 050000)
出处
《国际内分泌代谢杂志》
2022年第3期199-202,共4页
International Journal of Endocrinology and Metabolism
关键词
糖尿病肾脏病
异位脂质沉积
脂毒性
Diabetic kidney disease
Ectopic lipid deposition
Toxicity of fat
