摘要
目的探讨局部推拿联合脏腑点穴法治疗多发性抽动症(Tourette syndrome,TS)患儿的临床疗效。方法选取2017年3月—2020年3月期间河北省保定市第一中医院收治的TS患儿132例作为研究对象,采用随机数字表法将其分为A、B、C三组,每组各44例。3组患儿均给予西医治疗,B组行西医+局部常规推拿治疗,C组行西医+局部推拿+脏腑点穴法干预。治疗12周后,观察比较3组患儿治疗后临床疗效、中医证候评分;采用酶联免疫吸附法检测3组患儿治疗前后血清因子指标[血清γ-氨基丁酸(Gamma-aminobutyric acid,GABA)、谷氨酸(Glutamic Acid,GLU)及脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)]。结果治疗后3组患儿总有效率比较,差异无统计学意义(P>0.05);C组显效率50%(22/44)明显高于A组23.81%(10/42),差异有统计学意义(P<0.05)。3组患儿治疗后中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);且B组中医证候评分明显低于A组,C组明显低于A、B组,差异有统计学意义(P<0.05)。3组患儿治疗后血清GABA、BDNF水平均较治疗前升高,GLU均较治疗前降低,差异有统计学意义(P<0.05);且C组患儿血清GABA、BDNF水平明显高于A、B组,GLU水平明显低于A、B组,B组患儿血清GABA、BDNF水平明显高于A组,GLU水平明显低于A组,差异均有统计学意义(P<0.05)。结论局部推拿联合脏腑点穴法治疗TS患儿疗效显著,与其调整神经递质和神经营养因子水平有关。
Objective To study the clinical value of local massage combined with visceral acupoint massage therapy in the treatment of children with Tourette syndrome(TS).Methods A total of 132 children with TS treated in Baoding No.1 Hospital of Traditional Chinese Medicine from March 2017 to March 2020 were enrolled in this studyand assigned into groups A,B,and C according to the random number table method,with 44 children in each group.The children ingroups A,B,and C received western medicine,western medicine+local massage,and western medicine+local massage+visceral acupoint massage,respectively.The treatment lasted for 12 weeks and then therapeutic effect was compared among the three groups.The TCM syndrome scores were recorded before and after treatment.The enzyme-linked immunosorbent assay was employed to determine the levels of serum factors[γ-aminobutyric acid(GABA),glutamate(GLU),and brain-derived neurotrophic factor(BDNF)]before and after treatment.Results During the treatment,2 patients in group A voluntarily asked to quit,and 1 patient in group B lost to follow-up.The total effective rate showed no significant difference among the three groups(P>0.05).Group C had higher marked response rate[50%(22/44)vs.23.81%(10/42),P<0.05]than group A.After treatment,the TCM syndrome scores declined in all the three groups compared with those before treatment and showed a trend of group C<group B<group A(P<0.05).The treatments in all the three groups increased theserum levels of GABA and BDNF and decreased that of GLU(P<0.05).Moreover,theserum levels of GABA and BDNF showed a trend of group C>group B>group A,and that of GLU presented a trend ofgroup C<group B<group A(P<0.05).Conclusion Local massage combined with visceral acupoint massage therapy may regulate the levels of neurotransmitters and neurotrophic factors to treat TS in children.
作者
杨蕾
田苗
张瑶
马澜
张占玲
YANG Lei;TIAN Miao;ZHANG Yao;MA Lan;ZHANG Zhan-ling(Baoding No.1 Hospital of Traditional Chinese Medicine,Baoding Hebei 071000)
出处
《世界中西医结合杂志》
2022年第5期1030-1033,共4页
World Journal of Integrated Traditional and Western Medicine
基金
保定市科技计划项目(2041ZF127)。
关键词
局部推拿
脏腑点穴法
多发性抽动症
Local Massage
Visceral Acupoint Massage Therapy
Tourette Syndrome
