摘要
目的:观察六君子汤加味治疗老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效及对氧化应激、炎症反应的影响。方法:选取96例老年OSAHS患者,随机分为对照组和观察组各48例。对照组给予常规生活方式进行干预,观察组在对照组的基础上加用六君子汤加味治疗。比较2组临床疗效、中医证候积分、嗜睡量表(ESS)评分、氧化应激[超氧化物歧化酶(SOD)和丙二醛(MDA)]水平、炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)]水平及不良反应发生情况。结果:观察组总有效率为93.75%,对照组为77.08%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分、ESS评分比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分、ESS评分均较治疗前明显降低(P<0.05),且观察组中医证候积分、ESS评分均明显低于对照组(P<0.05)。治疗前,2组SOD、MDA水平比较,差异无统计学意义(P>0.05)。治疗后,2组SOD水平均较治疗前明显升高(P<0.05),MDA水平均较治疗前明显降低(P<0.05);且观察组SOD水平明显高于对照组(P<0.05),MDA水平明显低于对照组(P<0.05)。治疗前,2组TNF-α、IL-6、CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组TNF-α、IL-6、CRP水平均较治疗前明显降低(P<0.05),且观察组TNF-α、IL-6、CRP水平均低于对照组(P<0.05)。结论:在常规生活方式干预的基础上给予六君子汤加味治疗老年OSAHS疗效肯定,可改善患者中医证候和嗜睡程度,减轻机体氧化应激反应和炎症反应。
Objective:To observe the clinical effect of the therapy of modified Liujunzi tang on elderly patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and its effect on oxidative stress and inflammatory responses.Methods:A total of 96 elderly patients with OSAHS were randomly divided into the control group and the observation group,with 48 cases in each group.The control group was intervened with routine lifestyle,and the observation group was additionally treated with modified Liujunzi tang based on the treatment of the control group.The clinical effects,Chinese medicine syndrome scores,scores of Epworth Sleepiness Scale(ESS),levels of oxidative stress,including superoxide dismutase(SOD)and malondialdehyde(MDA),levels of inflammatory indexes,including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP),and adverse reactions were compared between the two groups.Results:The total effective rate was 93.75%in the observation group and 77.08%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of Chinese medicine syndrome and ESS between the two groups(P>0.05);after treatment,the above two scores in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above two scores in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of SOD and MDA between the two groups(P<0.05).After treatment,SOD levels in the two groups were significantly increased when compared with those before treatment(P<0.05),MDA levels were significantly decreased(P<0.05);the SOD level in the observation group was significantly higher than that in the control group(P<0.05),and MDA level was significantly lower(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of TNF-α,IL-6 and CRP between the two
出处
《新中医》
CAS
2022年第10期34-38,共5页
New Chinese Medicine
