摘要
目的观察尼可刹米、纳洛酮注射液联合氨茶碱注射液治疗急性呼吸衰竭的临床疗效。方法选取2018年1月—2020年1月恩施慧宜中西医结合风湿医院收治的急性呼吸衰竭患者80例,按照随机数字表法分为对照组和观察组,各40例。对照组予以尼可刹米,观察组在对照组基础上予以注射用盐酸纳洛酮联合氨茶碱注射液,2组均持续治疗7 d。比较2组临床疗效,治疗前后血气指标[pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))]、肺功能指标[第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)],临床症状缓解时间、住院时间,心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]及不良反应。结果观察组总有效率为95.0%,高于对照组的77.5%(χ^(2)=5.165,P=0.023)。治疗后,2组PaO_(2)、SaO_(2)高于治疗前,PaCO_(2)低于治疗前,观察组pH值低于治疗前,且观察组pH值、PaCO_(2)低于对照组,PaO_(2)、SaO_(2)高于对照组(P<0.05)。治疗后,观察组FEV_(1)、FEV_(1)/FVC高于治疗前,且观察组高于对照组(P<0.05)。观察组临床症状缓解时间、住院时间短于对照组(P<0.01)。治疗后,观察组LVEF高于对照组,LVEDD、LVESD小于对照组(P<0.01)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论尼可刹米、纳洛酮注射液联合氨茶碱注射液治疗急性呼吸衰竭的临床疗效确切,可有效改善患者的血气指标、肺功能以及临床症状,且安全性较高。
Objective To observe the clinical efficacy of nikethamide naloxone injection combined with aminophylline injection in the treatment of acute respiratory failure.Methods A total of 80 cases of patients with acute respiratory failure were selected from January 2018 to January 2020 in Enshi Huiyi Integrated Traditional Chinese and Western Medicine Rheumatism Hospital,which were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was given nikethamide,and the observation group was given naloxone hydrochloride combined with aminophylline injection on the basis of the control group.Both groups were continuously treated for 7 days.Clinical efficacy,blood gas indexes(pH value,PaO_(2),PaCO_(2),SaO_(2)),lung function indexes(FEV_(1),FEV_(1)/FVC)before and after treatment,clinical symptom relief time,hospitalization time,cardiac function indexes(LVEF,LVEDD,LVESD)and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.0%,higher than 77.5%of the control group(χ^(2)=5.165,P=0.023).After treatment,PaO_(2)and SaO_(2)in the two groups were higher than those before treatment,PaCO_(2)was lower than that before treatment,the pH value of the observation group was lower than that before treatment,and the pH value and PaCO_(2)in the observation group were lower than those in the control group,while PaO_(2)and SaO_(2)were higher than those in the control group(P<0.05).After treatment,FEV_(1),FEV_(1)/FVC in the observation group were higher than those before treatment,and those of the observation group were higher than control group(P<0.05).The clinical symptom relief time and hospitalization time in the observation group were shorter than those in the control group(P<0.01).After treatment,LVEF of observation group was higher than that of control group,LVEDD and LVESD were less than those of control group(P<0.01).There was no significant difference in the total incidence of adverse re
作者
郑臻
ZHENG Zhen(Enshi Huiyi Integrated Traditional Chinese and Western Medicine Rheumatism Hospital,Enshi 445000,China)
出处
《临床合理用药杂志》
2022年第15期23-25,29,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
急性呼吸衰竭
纳洛酮
氨茶碱
治疗结果
Acute respiratory failure
Naloxone
Aminophylline
Treatment outcome
