摘要
目的:探讨苏子降气汤联合氨茶碱对慢性肺心病伴呼吸衰竭患者肺功能及血清炎症因子的影响。方法:收集2017年12月—2019年12月78例慢性肺心病伴呼竭患者,随机分为两组,每组39例,对照组采用氨茶碱注射液1.0 g静脉滴注;观察组采用苏子降气汤联合氨茶碱注射液1.0 g静脉滴注,持续治疗10 d为1疗程。比较两组有效率、用力FVC、FEV1%、FEV1%/FVC及外周血高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)及白介素-6(IL-6)、血气分析指标等,记录不良反应状况。结果:对照组有效率79.49%(31/39),低于观察组有效率94.87%(37/39),差异有统计学意义(P<0.05)。治疗后两组FEV1%分别为(2.12±0.52)L,(2.71±0.58)L;FVC分别为(3.13±0.49)L,(3.74±0.51)L;FEV1%/FVC分别为(57.62±6.28),(65.73±7.13);外周血hs-CRP分别为(9.21±3.26)mg/L,(4.89±2.57)mg/L;外周血TNF-α分别为(28.75±3.10)pg/mL,(25.16±2.94)pg/mL;外周血IL-6分别为(19.81±3.79)pg/mL,(16.28±3.54)pg/mL;SPO_(2)含量分别为(91.55±6.02)%,(97.38±7.22)%;PaO_(2)含量分别为(70.44±7.27)mmHg,(76.83±7.30)mmHg;PaCO_(2)含量分别(68.33±7.03)mmHg,(63.88±6.52)mmHg。上述指标两组比较差异有统计学意义(P<0.05)。结论:苏子降气汤联合氨茶碱对慢性肺心病伴呼吸衰竭患者的疗效显著,能降低炎症因子水平,改善肺功能,患者可以耐受,值得广泛推广。
Objective:To investigate the effect of Suzi Jiangqi Decoction combined with Aminophylline in the treatment of chronic pulmonary heart disease with respiratory failure on pulmonary function and serum inflammatory factors.Methods:78 patients with chronic pulmonary heart disease and respiratory failure were randomly divided into the control group and the observation group,with 39 cases in each group.The control group was treated with Aminophylline Injection(1.0g,iv);on which basis,the observation group was also treated with Suzi Jiangqi Decoction(1.0g,iv).After 10 days of the treatment,clinical efficacy,FVC,FEV1%,FEV1%/FVC,hs-CRP,TNF-α and IL-6 were compared between the two groups,and the adverse reactions were recorded in the two groups.Results:The effective rate was 94.87%(37/39)in the observation group,which was significantly higher than 79.49%(31/39)in the control group(P<0.05).The level of FEV1% was(2.71±0.58)L,the level of FVC was(3.74±0.51)L and the level of FEV1%/FVC was(65.73±7.13)after the treatment in the observation group,which was significantly higher than(2.12±0.52)L,(3.13±0.49)L and(57.62±6.28)in the control group respectively.The peripheral blood levels of hs-CRP was(4.89±2.57)mg/L,the peripheral blood level of TNF-α was(25.16±2.94)pg/mL,and the peripheral blood level of IL-6 was(16.28±3.54)pg/mL after the treatment in the observation group,which was significantly lower than(9.21±3.26)mg/L,(28.75±3.10)pg/mL and(19.81±3.79)pg/mL respectively in the control group(P<0.05).The level of SPO_(2) was(97.38±7.22)% and the content of PaO_(2) was(76.83±7.30)mmHg after the treatment in the observation group,which was significantly higher than(91.55±6.02)% and(70.44±7.27)mmHg respectively in the control group(P<0.05);the content of PaCO_(2) was(63.88±6.52)mmHg after the treatment in the observation group,which was significantly lower than(68.33±7.03)mmHg in the control group(P<0.05).Conclusion:Suzi Jiangqi Decoction combined with Aminophylline is effective in treating chronic pulmonary heart
作者
丁睿
韩涛
DING Rui;HAN Tao(Benxi Hospital of TCM,Benxi 117000,China;State Ministry of Education Key Laboratory of Theory and Application of TCM Visceral Manifestations,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《中医药学报》
CAS
2022年第3期67-71,共5页
Acta Chinese Medicine and Pharmacology
基金
中国博士后科学基金特别资助项目(2017T100827)
辽宁中医药大学中医脏象理论及应用国家教育部重点实验室开放基金(zyzx1710)。
关键词
苏子降气汤
氨茶碱
慢性肺心病
呼吸衰竭
肺功能
炎症因子
Suzi Jiangqi Decoction
Aminophylline
Chronic pulmonary heart disease
Respiratory failure
Pulmonary function
Inflammatory factors
