摘要
目的:探讨氨茶碱联合孟鲁司特钠治疗支气管哮喘的临床疗效。方法:选取2012年9月至2015年12月海南省中医院收治的支气管哮喘患者150例,依据随机数字表法分为茶碱组和孟鲁茶碱组,每组75例。茶碱组患者在平喘、止咳、吸氧等治疗基础上给予氨茶碱治疗;孟鲁茶碱组患者在茶碱组治疗的基础上联合孟鲁司特钠治疗;采用哮喘控制测试(ACT)评估患者病情,酶联免疫吸附法(ELISA)检测患者血清C反应蛋白(CRP),比较两组患者治疗前、后肺功能相关指标、哮喘的控制及不良反应发生情况。结果:孟鲁茶碱组患者治疗后1秒钟用力呼气量/用力肺活量(FEV1/FVC)、呼气高峰流量(PEFR)明显高于茶碱组,血清CRP水平明显低于茶碱组;孟鲁茶碱组患者咳嗽、喘息、哮鸣音、湿啰音缓解时间明显短于茶碱组,治疗后7d、15d、30d的ACT得分明显高于茶碱组,差异均具有统计学意义(均P<0.05);茶碱组和孟鲁茶碱组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:氨茶碱联合孟鲁司特钠治疗可有效改善支气管哮喘患者肺功能和炎症状态,缓解其临床症状,提高哮喘控制效果,且并不增加不良反应发生风险,值得临床推广应用。
Objective： To explore the clinical efficacy of aminophylline combined with montelukast on the treatment of bronchial asthma. Methods： 150 patients with bronchial asthma treated in our hospital from September 2012 to December 2015 were recruited and randomly divided into two groups： the control group in which patients received basic treatment and aminophylline, and the combination group in which the pa- tients were treated as the control group with the addition of montelukast, with 75 eases in each group. The disease condition was assessed by asthma control test （ACT）. The level of c-reactive protein （CRP） was detected by enzyme-linked immunosorbent assay （ELISA）. The pulmonary function and the incidence of adverse reactions were compared between the two groups. Results： 1 s forced expiratory volume （FEV1）/forced vital capacity （FVC） ratio and peak expiratory flow （PEFR） were higher, while the CRP level in se- rum was lower in the combination group than those in the control group. Compared with the control group, the remission time of cough, wheezing, wheezing sound and wet rale was shorter in the combination group （P〈0.05）. After 7, 15 and 30-day treatment, the ACT score in the combination group was higher than that in the control group （P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）. Conclusion. Aminophylline combined with montelukast could effectively improve lung function, reduce inflammation reaction and alleviate clinical symptoms in patients with bronchial asthma, but it did not increase the adverse reactions. This combination has positive clinical significance.
作者
林文燕
Lin Wenyan.(Department of Respiratory Medicine, Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou 570203, Chin)
出处
《广西医科大学学报》
CAS
2017年第8期1197-1200,共4页
Journal of Guangxi Medical University
关键词
氨茶碱
孟鲁司特钠
支气管哮喘
肺功能
不良反应
aminophylline
montelukast
bronchial asthma
lung function
adverse reactions
