摘要
目的:研究草酸艾司西酞普兰联合阿戈美拉汀治疗抑郁症的应用效果。方法:选择2019年1月—2020年9月本院收治的抑郁症患者82例作为研究的对象,使用随机对照法将其分为研究组(n=41例)与对照组(n=41例),研究组应用草酸艾司西酞普兰10 mg/d+阿戈美拉汀25 mg/d睡前口服联合治疗,对照组予以草酸艾司西酞普兰10 mg/d睡前口服单独治疗。两组患者用药时间均持续4个月。比较两组患者用药后的治疗总有效率,用药前与用药后1、2、4和6周的汉密尔顿抑郁量表评分(HAMD)变化,治疗前后血清多巴胺(DA)、去甲肾上腺素(NE)及5-羟色胺(5-HT)指标变化及不良反应(头晕、恶心呕吐等)情况。结果:研究组患者治疗总有效率为92.68%,高于对照组的78.05%,但无统计学差异(P>0.05);两组患者治疗前HAMD评分无显著差异(P>0.05),治疗后两组患者的HAMD评分均较治疗前降低,且治疗后1、2、4和6周研究组HAMD评分均低于对照组(P<0.05);治疗前两组匹兹堡睡眠质量指数(PSQI)等级差异无统计学意义(P>0.05),治疗后,两组患者的PSQI等级情况均较治疗前改善,且研究组患者PSQI等级改善程度优于对照组(P<0.05);研究组睡眠改善有效率为90.24%,高于对照组的80.49%,但无统计学差异(P>0.05);治疗前两组患者血清DA、NE及5-HT含量无显著差异(P>0.05),治疗后两组患者血清上述指标均较治疗前升高,且研究组患者血清DA、NE和5-HT的水平均高于对照组(P<0.05);研究组不良反应总发生率为7.32%,低于对照组的14.63%,但差异无统计学意义(P>0.05)。结论:草酸艾司西酞普兰联合阿戈美拉汀治疗抑郁症可有效提高患者治疗效果,改善患者抑郁状态,促进实验室指标恢复,且具备较高的安全性。
Objective:To study the application effect of combination of escitalopram oxalate and agomelatine in treating depression.Methods:82 patients with depression admitted to our hospital,from January 2019 to September 2020 were selected as the research subjects,and they were randomly divided into the study group(n = 41)and the control group(n = 41)by using the randomized controlled method.The study group was treated with escitalopram oxalate 10 mg/d combined with agomelatine 25 mg/d orally before bedtime,while the control group was treated with escitalopram oxalate 10 mg/d orally before bedtime alone.The medication duration of both groups lasted four months.The total effective rate of both groups after treatment,the changes in Hamilton Depression Scale(HAMD) score before and 1,2,4,and 6 weeks after treatment,the changes in serum dopamine(DA),norepinephrine(NE),and 5-hydroxytryptamine(5-HT) levels and adverse reactions(dizziness,nausea,and vomiting,etc.) before and after treatment were compared.Results:The total effective rate in the study group was 90.24%,higher than 78.05% in the control group,but there was no significant difference(P>0.05).There was no significant difference in the HAMD scores between the two groups before treatment(P>0.05).The HAMD scores of the two groups after treatment were lower than those before treatment,and the HAMD scores of the study group were lower than those of the control group at 1,2,4,and 6 weeks after treatment(P<0.05).Before treatment,there was no significant difference in Pittsburgh sleep quality index(PSQI) scores between the two groups(P>0.05).After treatment,the PSQI scores of the two groups were improved compared with those before treatment,and the PSQI scores of the study group were better than those of the control group(P<0.05).The effective rate of sleep improvement in the study group was 90.24%,higher than 80.49% in the control group,but there was no significant difference(P>0.05).There was no significant difference in the levels of serum DA,NE,and 5-HT between the two grou
作者
王平生
Wang Pingsheng(Ruijin Ankang Psychiatric Hospital,Jiangxi342500)
出处
《天津药学》
2022年第3期39-43,共5页
Tianjin Pharmacy
