摘要
目的分析左西孟旦联合常规治疗对心力衰竭患者的疗效。方法抽取2018年2月至2021年2月南阳医学高等专科学校第一附属医院收治的心力衰竭患者152例,按随机数字表法分为研究组与常规组,每组76例。常规组采用常规治疗,研究组在常规组治疗基础上加用左西孟旦。比较两组疗效、治疗前后心率变异性指标[24 h内每5 min窦性R-R间期平均值的标准差(SDANN)、24 h内每5 min窦性R-R间期标准差的平均值(SDNNI)]、心室重构指标[左心室质量(LVMW)、室间隔厚度(IVST)、左心室舒张早期二尖瓣血流最大速度与左心室舒张晚期二尖瓣血流最大速度比值(E/A)]、心肌标志物[肌酸激酶同工酶(CKMB)、心肌钙蛋白T(cTnT)]水平和不良反应发生率。结果研究组总有效率(93.42%,71/76)高于常规组(82.89%,63/76),P<0.05。治疗后,研究组SDANN、SDNNI高于常规组(P<0.05);LVMW、IVST低于常规组,E/A高于常规组(P<0.05)。治疗后,研究组CKMB、cTnT水平低于常规组(P<0.05)。研究组不良反应发生率(19.74%,15/76)与常规组(14.47%,11/76)比较差异未见统计学意义(P>0.05)。结论左西孟旦联合常规治疗心力衰竭临床效果较好,可改善心率变异性和心室重构情况,调节心肌标记物表达,减轻心肌损伤,安全性良好。
Objective To analyze the effect of levosimendan combined with conventional therapy on patients with heart failure.Methods One hundred and fifty-two patients with heart failure treated in the First Affiliated Hospital of Nanyang Medical College from February 2018 to February 2021 were selected,and they were divided into study group and conventional group by random number table method,with 76 cases in each group.The conventional group was given conventional treatment,and the study group was treated with levosimendan based on the treatment of the conventional group.The efficacy of the two groups were compared;the heart rate variability,including standard deviation of the average normal-to-normal intervals in all 5-min(SDANN),standard deviation of normal-to-normal intervals index in all 5-min(SDNNI)within 24 hours,ventricular remodeling,including left ventricular mass(LVM),interventricular septal thickness(IVST),ratio of maximum mitral flow velocity in early left ventricular diastole to that in late left ventricular diastole(E/A),myocardial markers,including creatine kinase isozyme(CKMB),cardiac troponin T(cTnT)were compared between the two groups before and after treatment.And the incidence of adverse reactions of the two groups were compared.Results The total effective rate of the study group was 93.42%(71/76),which was higher than the 82.89%(63/76)of the conventional group(P<0.05).After treatment,SDANN and SDNNI of the study group were higher than those of the conventional group(P<0.05);LVMW and IVST of the study group were lower than those of the conventional group,and E/A was higher than that of the conventional group(P<0.05).After treatment,the levels of CKMB and cTnT of the study group were lower than those of the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(19.74%,15/76)and conventional group(14.47%,11/76),P>0.05.Conclusions Levosimendan combined with conventional therapy in the treatment of heart failure has significant clinical
作者
肜云鹏
陈豫贤
代聚平
Rong Yunpeng;Chen Yuxian;Dai Juping(Department of Cardiovascular Medicine Ward I,the First Affiliated Hospital of Nanyang Medical College,Nangyang 473000,China)
出处
《中国实用医刊》
2022年第7期109-112,共4页
Chinese Journal of Practical Medicine
关键词
心力衰竭
左西孟旦
心肌标志物
心室重构
心率变异性
Heart failure
Levosimendan
Myocardial markers
Ventricular remodeling
Heart rate variability
