摘要
目的探讨肺咳颗粒与奥美拉唑在小儿胃食管反流病并发肺炎中的应用效果。方法选取2020年4月至2021年5月北京市昌平区医院儿科收治的86例小儿胃食管反流病并发肺炎患儿作为研究对象,采用信封随机法将其分为对照组与观察组,每组各43例。对照组患者使用奥美拉唑治疗,观察组患儿使用肺咳颗粒与奥美拉唑治疗。比较两组患儿的疗效、临床症状消退时间、住院时间、治疗前后的生活质量指数评分量表(QOL)评分、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及不良反应发生情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者的呼吸困难、肺部啰音症状消退时间与住院时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的QOL评分与hs-CRP、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗1个月后,观察组患者的QOL评分高于对照组,hs-CRP、IL-6、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对小儿胃食管反流并发肺炎患儿使用肺咳颗粒与奥美拉唑可获得较好的治疗效果,能够快速缓解其临床症状,减轻炎症损伤,改善生活质量,且不良反应较少,具有临床推广价值。
Objective To investigate the application effect of Feike Granule and Omeprazole in children with gastroesophageal reflux disease complicated with pneumonia.Methods A total of 86 children with gastroesophageal reflux disease complicated with pneumonia treated in pediatrics of Changping District Hospital of Beijing from April 2020 to May 2021 were selected as the research objects and randomly divided into the control group and the observation group,with 43 cases in each group.The control group was treated with Omeprazole,and the observation group was treated with Feike Granule and Omeprazole.The curative effect,regression time of various clinical symptoms,hospitalization time,the quality of life score(QOL)before and after treatment,the high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor were detected-α(TNF-α)and the adverse reactions of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The remission time of dyspnea,lung sounds and hospitalization time in the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the QOL scores and level of hs-CRP,IL-6 and TNF-αof the two groups(P>0.05).After one month of treatment,the QOL score of the observation group was higher than that of the control group,the hs-CRP,IL-6 and TNF-αlevels were lower than those of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of Feike Granule and Omeprazole in children with gastroesophageal reflux complicated with pneumonia can achieve better therapeutic effect,which can quickly alleviate their clinical symptoms,reduce inflammatory injury,improve the quality of life,and ha
作者
赵静
ZHAO Jing(Department of Pediatrics,Changping District Hospital of Beijing,Beijing102200,China)
出处
《中国当代医药》
CAS
2022年第17期112-115,共4页
China Modern Medicine
关键词
小儿胃食管反流病
肺炎
肺咳颗粒
奥美拉唑
疗效
Gastroesophageal reflux disease in children
Pneumonia
Feike Granule
Omeprazole
Curative effect
