摘要
基于纳米粒子的光热疗法利用在肿瘤组织中富集的纳米粒子转化光能所引起的局部升温抑制肿瘤。然而,由于光穿透深度以及热休克蛋白等因素的限制,单一光热治疗效果有限,需要结合其他疗法实现协同治疗。免疫疗法同样面临效率低以及免疫抑制等挑战。而这两种疗法相结合能有效地弥补各自的不足,发挥协同作用,有望在消除原发肿瘤的基础上预防复发、抑制转移。该文系统性介绍了用于光热疗法的纳米粒子,概述了基于纳米粒子的光热协同抗原、免疫佐剂、免疫检查点等免疫疗法以及辅助策略在肿瘤治疗中的研究进展,并对未来的发展方向进行讨论和展望,旨在为肿瘤治疗模式的创新以及纳米医学的发展提供新思路。
Nanoparticle-based photothermal therapy inhibits tumors through local temperature rise converted from light energy,which is caused by nanoparticles enriched in tumor tissue.However,due to the limitations of light penetration depth and heat shock proteins,the effect of single photothermal therapy is dissatisfactory.At this stage,it is necessary to combine other therapeutic strategies with photothermal therapy to achieve synergistic treatment.Meanwhile,immunotherapy faces many challenges such as inefficiency and immunosuppression.The combination of these two therapies can effectively make up for their deficiencies and play a synergistic role,which is expected to prevent recurrence and inhibit metastasis on the basis of eliminating the primary tumor.This manuscript systematically introduces nanoparticles for photothermal therapy,reviews the research status of nanoparticle-based photothermal therapy in combination with antigens,immune adjuvants,checkpoint immunotherapy,and other immunotherapeutic strategies as well as auxiliary strategies,prospects and discusses the future development directions,aiming to provide new ideas for the innovation of tumor therapeutic mode and the development of nanomedicine.
作者
徐榴
汪建华
XU Liu;WANG Jianhua(School of Medicine,Ningbo University,Ningbo 315000,China)
出处
《生命的化学》
CAS
2022年第2期224-232,共9页
Chemistry of Life
基金
国家自然科学基金项目(8217071207)
浙江省自然科学基金项目(LY20H180008)。
关键词
光热疗法
免疫疗法
靶向策略
可视化策略
photothermal therapy
immunotherapy
targeting strategy
visualization strategy
