摘要
目的传统的光疗剂容易被免疫系统识别、血液循环快速清除和在肿瘤部位聚集较低等问题进一步降低了光疗疗效。采用细胞膜仿生修饰已成为一种潜在的改善策略,因此,对细胞膜仿生修饰纳米粒在癌症光疗中的应用进行综述。方法通过查阅近五年的相关文献,对细胞膜修饰纳米粒在癌症光疗中的应用进行分类和总结。结果不同来源的细胞膜可运用多种制备手段包裹在纳米粒表面,且不会改变其光物理性质。修饰后的纳米粒还赋予了诸多生理学功能,如免疫逃逸、延长体内循环时间、同源靶向等。结论本文综述了红细胞、肿瘤细胞、干细胞、血小板或巨噬细胞等几种典型细胞膜的优劣势,旨在为细胞膜仿生策略用于癌症光疗中的发展提供新思路。
Objective Conventional phototherapeutic agents are easily recognized by the immune system,rapidly cleared by the blood circulation,and low accumulation in the tumor,which further reduce the therapeutic efficacy of phototherapy.Cell membrane coating nanoparticles has emerged as a prospective strategy.Therefore,this review aims to summarize the advances of cell membrane-coated nanoparticles for cancer phototherapy.Methods The application of cell membranes coated nanoparticles in cancer phototherapy was classified and summarized by deeply collecting relevant literature data.Results Membranes from different cell can be coated on the nanoparticles by plenty preparation methods without changing the photophysical properties.The modified nanoparticles are also endowed with many additional physiological functions including immune escape,prolonged circulation time and homologous targeting and so on.Conclusion This review summarizes the advantages and disadvantages of several typical cell membranes such as erythrocytes,cancer cells,stem cells,platelets or macrophages.Therefore,this review will provide new thoughts of the cell membrane-camouflaged nanoparticles in cancer phototherapy.
作者
李悦
尚靖
夏琪
陈佳
殷佩浩
袁泽婷
LI Yue;SHANG Jing;XIA Qi;CHEN Jia;YIN Peihao;YUAN Zeting(Central Laboratory,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Interventional Cancer Institute of Chinese Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;College of Pharmacy,East China University of Science and Technology,Shanghai 200237,China)
出处
《沈阳药科大学学报》
CAS
CSCD
2024年第1期13-24,共12页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金资助项目(81973700)
上海市普陀区卫生健康系统科技创新项目(ptkwws202004)
上海中医药大学科技发展基金项目(23KFL084)。
关键词
细胞膜
光疗
纳米粒
肿瘤
cell membrane
phototherapy
nanoparticle
tumor
