摘要
目的探讨老年体检者代谢综合征(MS)与慢性肾脏病(CKD)早期肾功能损伤之间的相关性。方法选择2017年9月至2018年8月在四川省人民医院健康管理中心完成健康体检且年龄≥60岁的老年体检者,收集疾病史和生活习惯等生活方式信息及身高、体重、腰围、血压、空腹血脂、血糖、肌酐以及晨尿尿常规、尿蛋白和尿隐血等信息,分析该人群MS和CKD早期肾功能损伤的检出情况、MS及其各代谢异常组分与CKD早期肾功能损伤的相关性。结果共纳入2975例研究对象,年龄60~92(67.10±5.98)岁,老年人群MS的检出率为32.34%(962/2975),CKD早期肾功能损伤的检出率为28.84%(858/2975)。受检者中MS患者的CKD早期肾功能损伤的检出率为37.63%(362/962),高于非MS患者的CKD早期肾功能损伤检出率24.64%(496/2013),差异有统计学意义(χ^(2)=53.52,P<0.001);MS患者的尿白蛋白/肌酐比值(ACR)检出率均明显高于非MS患者[31.91%(307/962)比17.49%(352/2013)],差异有统计学意义(χ^(2)=78.56,P<0.001)。中心性肥胖、血压升高、血糖升高均会增加CKD的患病风险(OR=1.44、1.82、1.74,均P<0.05)。随着代谢异常组分的增加,CKD的患病风险增加。结论MS是CKD早期肾功能损伤发生的危险因素,早期控制和治疗MS对降低CKD发病率和延缓CKD进展具有重要意义。
Objective To explore the correlation between metabolic syndrome(MS)and early renal function injury in chronic kidney disease(CKD)in the healthy elderly subjects having passed through a healthy physical examination.Methods These healthy elderly subjects aged≥60 years in the Sichuan Provincial People's Hospital health management center from September 2017 to August 2018 were randomly selected to collect lifestyle information such as disease history and living habits,as well as health information such as height,weight,waist circumference,blood pressure,fasting blood lipid,blood glucose,creatinine,morning urine routine,urinary protein and urinary occult blood.The detection situation of MS and early renal function injury of chronic kidney disease,and the correlation of MS and its abnormal components with early renal function injury of CKD were analyzed.Results A total of 2975 subjects,aged from 60 to 92 years old,with mean age of(67.10±5.98)years old,were enrolled.The detection rate of MS and early renal function impairment in CKD was 32.34%(962/2975)and 28.84%(858/2975)respectively.The detection rate of early CKD renal function injury in MS patients was 37.63%(362/962),which was higher than that in non-MS patients(24.64%)(496/2013)(χ^(2)=53.52,P<0.001).The prevalences of CKD and albumin/creatinine ratio(ACR)in MS patients were significantly higher than those in non-MS patients[31.91%(307/962)versus 17.49%(352/2013)]with the difference being statistically significant(χ^(2)=78.56,P<0.001).Central obesity,elevated blood pressure and elevated blood glucose increased the risk of CKD(OR=1.44,1.82 and 1.74 respectively,all P<0.05).Along with the increase of number of metabolic abnormal components,the risk of CKD increased.Conclusions MS is a risk factor for early renal function impairment in CKD.Early control and treatment of MS are of great significance in reducing the incidence rate of CKD and delaying CKD progression.
作者
姚晓琴
刘玉萍
王林
帅平
杨华
蒋丽
左晓娇
唐智
Yao Xiaoqin;Liu Yuping;Wang Lin;Shuai Ping;Yang Hua;Jiang Li;Zuo Xiaojiao;Tang Zhi(Health Management Center,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China;Department of Orthopedics,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2022年第6期669-673,共5页
Chinese Journal of Geriatrics
基金
四川省干部保健科研项目(川干研2017-225)。
关键词
肾疾病
代谢综合征
肾功能不全
Kidney diseases
Metabolic syndrome
Renal insufficiency
